Shock-Induced Arrhythmogenesis in Regional Myocardial Ischemia

这个项目将提高对缺血情况下除颤机制的理解。由于很大一部分心律失常发生在这种情况下，这是一个重大的临床问题。这项提议的目的是建立一个兔心室的三维模型，并研究心脏对除颤电击的反应如何因缺血而改变。该项目可能会对开发更好的除颤器以防止心脏性猝死产生影响。

0601935TrayanovaThis project will improve the understanding of defibrillation mechanisms in the context of ischemia. Since a large fraction of cardiac arrhythmias occur in this setting, this is a significant clinical problem. The goal of this proposal is to develop a 3-D model of the rabbit ventricle and to study how the response of the heart to defibrillation shocks is altered by ischemia. This project could have an impact in the development of better defibrillators to prevent sudden cardiac death.