RUI: Electronic and Molecular Structure of Paramagnetic Iron Parphyrins Probed by NMR Spectroscopy

RUI：通过核磁共振波谱探测顺磁性铁卟啉的电子和分子结构

• 批准号: 9816356
• 负责人: Ursula Simonis
• 金额: $ 27万
• 依托单位: San Francisco State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9816356&HistoricalAwards=false
• 关键词: RUI; Electronic; Molecular; Structure; Paramagnetic

With this New RUI award, the Inorganic, Bioinorganic and Organometallic Chemistry Program is supporting the work of Dr. Ursula Simonis of San Francisco State University. The project combines two-dimensional Nuclear Magnetic Resonance spectroscopy, computational chemistry, and X-ray crystallography to provide a quantitative description of, and the factors that affect the electron spin density delocalization in hemeproteins. The results will permit assignments of hyperfine-shifted resonances of paramagnetic iron porphyrins and allow a prediction of the most likely mechanisms of reactions at the heme periphery.The results from this project will be of interest to applications in the related magnetic resonance imaging (MRI) field and to health-related research. Master's students and a large number of undergraduate students from under-represented groups will be involved in these studies. The project will provide hands-on access to sophisticated scientific instrumentation, and will give these students a valuable educational experience to prepare them to meet the challenges they will face in a very competitive workforce arena or in the pursuit of further education to the Ph.D. level.

有了这个新的RUI奖，无机，生物无机和有机化学计划是支持博士的工作。乌苏拉Simonis旧金山弗朗西斯科州立大学。该项目结合了二维核磁共振光谱，计算化学和X射线晶体学，提供了一个定量的描述，以及影响血红素蛋白中电子自旋密度离域的因素。结果将允许顺磁性铁卟啉的超精细位移共振的分配，并允许在血红素peripher.The结果最有可能的反应机制的预测将在相关的磁共振成像（MRI）领域的应用和健康相关的研究。来自代表性不足群体的硕士生和大量本科生将参与这些研究。该项目将提供动手访问复杂的科学仪器，并将给这些学生一个宝贵的教育经验，以准备他们迎接挑战，他们将面临一个非常有竞争力的劳动力竞技场或在追求进一步的教育博士学位。水平