Acquisition of a 500 MHz NMR Spectrometer to Enhance Research and Research Training Opportunities at the Department of Chemistry & Biochemistry at San Francisco State Universit

采购 500 MHz 核磁共振波谱仪以增强化学系的研究和研究培训机会

• 批准号: 0521342
• 负责人: Ursula Simonis
• 金额: $ 64.24万
• 依托单位: San Francisco State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2008-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0521342&HistoricalAwards=false
• 关键词: Acquisition; 500; MHz; NMR; Spectrometer

This award supports the acquisition of a high-resolution, high-field 500 MHz NMR spectrometer that is equipped with pulsed field gradient, cross-polarization magic angle spinning (CPMAS), and variable temperature accessories, as well as a multinuclear observe, an inverse broadband, and a CPMAS probe. The specific aims of the project are to (i) expand the research opportunities of ten faculty members in the Department of Chemistry & Biochemistry, their research students, and laboratory personnel in two of the focus areas central to the research and teaching mission of the Department, namely structure/function relationships of biomolecules and materials chemistry, and open up new lines of investigation; (ii) enhance and facilitate collaborative research with Ph.D. granting institutions or the private sector; and (iii) increase the research activities of a diverse undergraduate and graduate student population through access and training in the practical applications of liquid and solid state NMR spectroscopy at high field. In the area related to structure and function of biomolecules, the NMR spectrometer will allow new insights to be obtained in the (i) study of porphyrinic and metalloporphyrinic pigments incorporated in model membrane systems; (ii) synthesis of structurally complex alkaloids; (iii) understanding of structure/function relationships of metalloenzymes, of metallopeptidase inhibitors, and of enzyme substrate analogs involved in DNA and RNA biosynthesis; (iv) study of gas-phase salt complex substitution and elimination reactions emphasizing chiral recognition; and (v) study of metabolic pathways and mitochondrial complexes I and II. In the materials or environmentally relevant materials chemistry area, solid and liquid state NMR spectroscopy will facilitate research on (i) novel zeolite intercalation compounds, (2) the cycling and fate of organic matter in the environment, (iii) reactions of arsenic on mineral, metal oxide, and remediation material surfaces, and in silicon tetraazaannulene complexes that are studied in collaboration with the private sector. The acquisition of this instrument will provide unique opportunities to a diverse student body in both the research and instructional programs to acquire hands-on training in modern aspects of NMR spectroscopy. Acquisition of this instrument will jumpstart the research careers of recently hired minority and women faculty members and empower them to pursue new lines of biomolecular or materials chemistry research, or to establish themselves as role models in the applications of solid-state NMR spectroscopy to the fate of organic matter in the environment. As a minority-serving campus, SFSU is proud to be a leader in the education of a student body that is comprised of 68% non-white ethnicity students and 61% women. Thus, the training in modern high-field NMR applications combined with the collaborative student-faculty research focus will prepare the Department's diverse student body for the challenges awaiting them in Ph.D. programs and the workforce.

该奖项支持购买高分辨率、高场500 MHz NMR光谱仪，该光谱仪配备脉冲场梯度、交叉极化魔角旋转（CPMAS）和可变温度附件，以及多核观测器、反向宽带和CPMAS探头。 该项目的具体目标是（i）扩大化学生物化学系十名教师，他们的研究生和实验室人员在该部门研究和教学使命的两个重点领域的研究机会，即生物分子和材料化学的结构/功能关系，并开辟新的研究领域;（ii）加强和促进与博士合作研究。（iii）通过在高场液体和固体核磁共振光谱学的实际应用方面的机会和培训，增加多样化本科生和研究生群体的研究活动。 在与生物分子的结构和功能有关的领域，NMR光谱仪将使人们能够在以下方面获得新的认识：（i）研究模型膜系统中的卟啉和金属卟啉色素;（ii）合成结构复杂的生物碱;（iii）理解金属酶、金属肽酶抑制剂以及DNA和RNA生物合成中所涉及的酶底物类似物的结构/功能关系;（iv）研究生物分子的结构和功能。（iv）研究气相盐络合物取代和消除反应，强调手性识别;以及（v）研究代谢途径和线粒体络合物I和II。 在材料或与环境相关的材料化学领域，固态和液态NMR光谱将促进以下方面的研究：（i）新型沸石插层化合物，（2）环境中有机物质的循环和命运，（iii）砷在矿物，金属氧化物和补救材料表面的反应，以及与私营部门合作研究的硅四氮杂轮烯复合物。 该仪器的收购将提供独特的机会，以不同的学生团体在研究和教学计划，以获得动手培训的现代方面的NMR光谱。 该仪器的收购将启动最近聘请的少数民族和女性教职员工的研究生涯，并使他们能够追求生物分子或材料化学研究的新路线，或建立自己作为固态NMR光谱应用的榜样环境中有机物的命运。 作为一个少数民族服务的校园，SFSU很自豪能成为一个由68%的非白人学生和61%的女性组成的学生团体的教育领导者。 因此，现代高场NMR应用的培训与合作的学生-教师研究重点相结合，将为该部门的多样化学生群体准备迎接博士学位的挑战。方案和劳动力。