Purchase of Integrated Fluorescence, Polarized Fluorescence and Brewster Angle Microscope/Langmuir Trough Instrumentation for Studies of Lipid-Protein Interactions at Interfaces

购买集成荧光、偏光荧光和布鲁斯特角显微镜/朗缪尔槽仪器用于研究界面处的脂质-蛋白质相互作用

• 批准号: 9816513
• 负责人: James Norris
• 金额: $ 9.91万
• 依托单位: University of Chicago
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-01 至 2001-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9816513&HistoricalAwards=false
• 关键词: Purchase; Integrated; Fluorescence; Polarized; Brewster

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program will enable the Chemistry Department at the University of Chicago to purchase a combination fluorescence and Brewster angle microscope/Langmuir trough instrument. This equipment will be used primarily by junior faculty member Ka Yee C. Lee, whose research focuses on the study of lipid-protein interactions at interfaces; interactions between proteins and lung surfactant-specific lipids; and the role of membrane lipids in the aggregation of amyloid beta peptides. Dr. Lee's research, which involves surface chemical investigations of the interactions of surface-active peptides with lipid monolayers at the air-water interface, has considerable practical merit as well as fundamental significance. The applications are sure to yield interesting new knowledge regarding important biological systems. In addition, it is quite likely that the results will be highly relevant to lung diseases involving premature infants and emphysema; thus, there should be a significant beneficial effect on society at large.

化学研究仪器和设施（CRIF）计划的这一奖项将使芝加哥大学化学系能够购买组合荧光和布鲁斯特角显微镜/朗缪尔槽仪器。 这些设备将主要由初级教员嘉仪C使用。Lee博士的研究重点是界面处脂质-蛋白质相互作用的研究;蛋白质与肺表面活性剂特异性脂质之间的相互作用;以及膜脂质在淀粉样β肽聚集中的作用。 李博士的研究涉及表面活性肽与脂单分子层在空气-水界面上相互作用的表面化学研究，具有相当大的实际价值和根本意义。 这些应用肯定会产生关于重要生物系统的有趣的新知识。 此外，研究结果很可能与涉及早产儿和肺气肿的肺部疾病高度相关;因此，应该对整个社会产生重大的有益影响。