Acquisition of Mass Spectrometers and X-ray Diffractometer

化学研究仪器和设施（CRIF）和主要研究仪器（MRI）计划的这一奖项将使芝加哥大学化学系获得两台质谱仪和一台X射线衍射仪。这一设备将加强若干领域的研究，包括研究大型多电荷金属络合物，重点是金属络合物和超分子组合体以及客体的结合;合成立方烷类似物;研究高压材料;合成和研究非常小的活性氮络合物;研究镍（II）体系中的还原消除反应;亲电金属络合物化学;分子识别;生物有机化学和化学生物学;在金上的烷硫醇盐的自组装单层作为理解和控制哺乳动物细胞-基质相互作用的模型表面;生物催化，例如，由核酶催化的磷酰基转移反应;用卡宾络合物合成中到大环;以及新型功能和多功能聚合物和分子的合理设计、合成和表征。 质谱（MS）是一种用于探测紧密结构细节并获得大量有机、生物有机和有机金属分子的分子组成的技术。 X射线衍射仪可以精确测量分子的完整三维结构，包括键距和角度，并提供有关分子相对于相邻分子的空间排列的准确信息。 这套仪器将促进生物化学，材料科学和一般合成化学以及生物和地球物理科学的研究。

This award from the Chemistry Research Instrumentation and Facilities (CRIF) and the Major Research Instrumentation (MRI) Programs will allow the Department of Chemistry at the University of Chicago to acquire two mass spectrometers and an X-ray diffractometer. This equipment will enhance research in a number of areas, including studies of large multi-charged metal complexes with an emphasis on bimetallic complexes and supramolecular assemblies and guest incorporation; synthesis of cubane analogs; studies of materials at high pressures; synthesis and study of very small, reactive hydrides of nitrogen; investigations of reductive elimination reactions in nickel(II) systems; chemistry of electrophilic metal complexes; molecular recognition; bioorganic chemistry and chemical biology; self-assembled monolayers of alkanethiolates on gold as model surfaces for understanding and controlling mammalian cell-substrate interactions; biological catalysis, for example, phosphoryl transfer reactions catalyzed by ribozymes; medium to large ring synthesis with carbene complexes; and the rational design, synthesis and characterization of novel functional and multifunctional polymers and molecules. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The X-ray diffractometer allows accurate and precise measurements of the full three dimensional structure of a molecule, including bond distances and angles, and it provides accurate information about the spatial arrangement of the molecule relative to the neighboring molecules. This suite of instruments will facilitate research in biological chemistry, materials science, and general synthetic chemistry, as well as biological and geophysical sciences.