NSF-CGP Fellowship: Dispensing and Metering of Nanoliter Liquid Volumes

NSF-CGP 奖学金：纳升液体体积的分配和计量

• 批准号: 9819282
• 负责人: Thomas Jones
• 金额: $ 6.33万
• 依托单位: University of Rochester
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-15 至 2001-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9819282&HistoricalAwards=false
• 关键词: NSF; CGP; Fellowship; Dispensing; Metering

9819282JonesThis award provides funds to support a 9-month research visit by Dr. Thomas Byron Jones, Department of Electrical and Computer Engineering, University of Rochester, for collaboration with Dr. Masao Washizu, Department of Mechanical Engineering, Kyoto University, Japan. The goal of their research is to develop and test microelectrode systems for manipulation and control of nanoliter-sized liquid volumes using dielectrophoretic (DEP) forces. DEP liquid control offers the prospect of enhanced functionality for IOTAS (micro total analysis systems) for chemical and cellular/biological processes, especially in applications where available liquid or cell samples are very small, toxic, or biologically hazardous, or where strict isolation of samples must be maintained. A long-term objective would be programmable systems where liquid injected by a micropipette is dispensed reproducibly into nanoliter droplets for transport one-at-a-time across a substrate for such processing as laser-optical or dielectrometric assay, mixing, or separation.The experimental approach in this research will integrate the new electric field-actuated droplet transport scheme, developed by the host, with DEP liquid handling to meter and dispense aqueous solutions and chemical compounds in liquid form. Once successful in demonstrating voltage-actuated droplet dispensing, the collaborators will integrate the electrode structure with the droplet transport scheme to create a very basic m-TAS device. The ultimate objective will be a voltage-controlled structure that draws a microliter volume of liquid from a reservoir (probably via a dielectric siphon) and then dispenses this into nanoliter droplets. The project will be mutually beneficial because of the complementary expertise of the collaborators which will contribute to the two-way exchanges of ideas, skills, and techniques planned for this research. This project is supported under the Science Fellowship Program between the National Science Foundation and the Japan Foundation Center for Global Partnership.***

9819282琼斯该奖项提供资金支持罗切斯特大学电气与计算机工程系的托马斯拜伦琼斯博士与日本京都大学机械工程系的Masao Washizu博士合作进行为期9个月的研究访问。 他们的研究目标是开发和测试微电极系统，用于使用介电泳（DEP）力操纵和控制纳升大小的液体体积。 DEP液体控制为化学和细胞/生物过程的IOTAS（微全分析系统）提供了增强功能的前景，特别是在可用液体或细胞样品非常小、有毒或具有生物危害的应用中，或者必须保持样品严格隔离的应用中。 一个长期的目标将是可编程的系统，其中由微量移液管注入的液体可重复地分配成纳升液滴，用于在基板上一次一个地传输，用于激光光学或介电测定、混合或分离等处理。与DEP液体处理计量和分配水溶液和液体形式的化合物。 一旦成功演示了电压驱动的液滴分配，合作者将把电极结构与液滴传输方案整合在一起，以创建一个非常基本的m-TAS设备。最终的目标将是一个电压控制的结构，从一个水库（可能通过一个介电虹吸管）吸取微升体积的液体，然后将其分配到纳升液滴。 该项目将是互惠互利的，因为合作者的互补专业知识将有助于双向交流的想法，技能和技术计划为这项研究。 该项目由国家科学基金会和日本基金会全球伙伴关系中心之间的科学奖学金计划提供支持。