PECASE: Engineering the Human Airway to Study the Transport and Kinetics of S-nitrosothiols
PECASE:改造人类气道以研究 S-亚硝基硫醇的转运和动力学
基本信息
- 批准号:9875033
- 负责人:
- 金额:$ 23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-05-01 至 2003-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
9875033GeorgeThis CAREER proposal describes a Research Plan devoted to the design of artificial lung tissue that will be used to study a class of molecules called S-nitrosothiols (RS-NO), and a Teaching Plan devoted to the incorporation of Problem-Based Learning into the engineering curriculum. RS-NO compounds can be inhaled, and hold promise as a potential source of nitric oxide to lung tissue. Nitric oxide can relax smooth muscle in the lung, and this feature is beneficial to several important diseases such as asthma and Adult Respiratory Distress Syndrome (ARDS). The objectives of the project are to: 1) engineer and characterize a model of lung tissue which can be used to study physical and chemical properties of biological molecules, 2) characterize the chemistry RS-NO in lung tissue including the effect of active disease, and 3) design therapeutic strategies which optimize the concentration of nitric oxide at smooth muscle sites following the inhalation of RS-NO. Completion of the Research Plan will not only provide the pivotal information necessary to fully investigate the therapeutic potential of RS-NO in the treatment of inflammatory diseases such as bronchial asthma, but will also provide an important model system that can be used in a wide range of future airway studies. The main objective of the Teaching Plan is the incorporation of Problem-Based Learning (PBL) techniques into the undergraduate and graduate engineering curriculum. PBL is a method that allows not only the acquisition of basic facts and laws associated with the discipline, but strongly encourages the development of less tangible, but perhaps more important, skills of the practicing engineer which include reasoning, judgment, and innovation. Secondary objectives include the incorporation of research results from the Research Plan into the curriculum and peer-assessment. Completion of the Teaching Plan will introduce a new method of teaching engineering concepts that in the long term will produce more creative and effective engineers.
这份职业建议书描述了一份致力于人工肺组织设计的研究计划,该计划将用于研究一类名为S-亚硝硫醇(RS-NO)的分子,以及一份致力于将基于问题的学习纳入工程课程的教学计划。RS-NO化合物可以被吸入,并有望成为肺组织一氧化氮的潜在来源。一氧化氮可以松弛肺中的平滑肌,这一特征对哮喘和成人呼吸窘迫综合征(ARDS)等几种重要疾病都有好处。该项目的目标是:1)设计和表征可用于研究生物分子的物理和化学性质的肺组织模型;2)表征肺组织中的化学RS-NO,包括活动性疾病的影响;3)设计治疗策略,以优化吸入RS-NO后平滑肌部位的一氧化氮浓度。研究计划的完成不仅将提供充分研究RS-NO在治疗哮喘等炎症性疾病方面的治疗潜力所需的关键信息,而且还将提供一个重要的模型系统,可用于未来广泛的呼吸道研究。教学计划的主要目标是将基于问题的学习(PBL)技术纳入本科生和研究生的工程课程。PBL是一种方法,它不仅允许获得与该学科相关的基本事实和规律,而且强烈鼓励实践工程师发展不那么有形但可能更重要的技能,包括推理、判断和创新。次级目标包括将研究计划的研究成果纳入课程和同行评估。教学计划的完成将引入一种教授工程概念的新方法,从长远来看,这种方法将培养出更具创造力和效率的工程师。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Steven George其他文献
Assessing Referral Bias In An Embedded Pragmatic Cluster Randomized Trial For Veterans With Low Back Pain
评估退伍军人腰痛嵌入式实用集群随机试验中的转诊偏倚
- DOI:
10.1016/j.jpain.2023.02.172 - 发表时间:
2023-04-01 - 期刊:
- 影响因子:4.000
- 作者:
Cynthia Coffman;Janet Grubber;Courtni France;Adam Goode;Kelli Allen;Steven George;Susan Hastings - 通讯作者:
Susan Hastings
Aerodynamic Drag Measurements of FIFA-approved Footballs
国际足联批准的足球的空气动力学阻力测量
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:0
- 作者:
F. Alam;H. Chowdhury;Steven George;I. Mustary;G. Zimmer - 通讯作者:
G. Zimmer
Tu1258 - Development of Patient-Derived “Small Intestine-On-A-Chip” Microfluidic Devices
- DOI:
10.1016/s0016-5085(18)33084-1 - 发表时间:
2018-05-01 - 期刊:
- 影响因子:
- 作者:
Kristen Seiler;Michael Binkley;David M. Alvarado;Micah Iticovici;William Goo;Kelli L. VanDussen;Thaddeus Stappenbeck;Deborah C. Rubin;Steven George;Matthew A. Ciorba;Mark Meacham;Brad W. Warner - 通讯作者:
Brad W. Warner
Moving Towards Patient-Centered Care in the Emergency Department: Importance of Improvement in Pain-Related Outcomes
- DOI:
10.1016/j.jpain.2021.03.063 - 发表时间:
2021-05-01 - 期刊:
- 影响因子:
- 作者:
Spencer Flynn;Alexander Gordee;Maragatha Kuchibhatla;Steven George;Stephanie Eucker - 通讯作者:
Stephanie Eucker
361 - Lower Positive Coping is Associated with Higher Movement-Evoked Pain Among Adults with Low Back Pain
361 - 较低的积极应对与腰痛成年人中较高的运动诱发疼痛相关
- DOI:
10.1016/j.jpain.2025.105159 - 发表时间:
2025-04-01 - 期刊:
- 影响因子:4.000
- 作者:
Isabelle Botto;Steven George;Emily Fox;Katie Butera - 通讯作者:
Katie Butera
Steven George的其他文献
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{{ truncateString('Steven George', 18)}}的其他基金
Fundamental Issues for Thermal Atomic Layer Etching
热原子层蚀刻的基本问题
- 批准号:
1609554 - 财政年份:2016
- 资助金额:
$ 23万 - 项目类别:
Standard Grant
Hybrid Organic-Inorganic Films Grown by Molecular Layer Deposition as Precursors to Conformal Metal Oxide-Carbon Composite and Porous Metal Oxide Films
通过分子层沉积作为共形金属氧化物-碳复合材料和多孔金属氧化物薄膜前驱体生长的有机-无机杂化薄膜
- 批准号:
1306131 - 财政年份:2014
- 资助金额:
$ 23万 - 项目类别:
Standard Grant
Molecular Layer Deposition of Hybrid Organic-Inorganic Polymer Films with Tunable Mechanical Properties
具有可调机械性能的杂化有机-无机聚合物薄膜的分子层沉积
- 批准号:
1012116 - 财政年份:2010
- 资助金额:
$ 23万 - 项目类别:
Continuing Grant
Molecular Layer Deposition of Polymers: Nucleation, Surface Chemistry and Nanocomposite Films
聚合物的分子层沉积:成核、表面化学和纳米复合薄膜
- 批准号:
0715552 - 财政年份:2007
- 资助金额:
$ 23万 - 项目类别:
Continuing Grant
In Situ Probing of Atomic Layer Deposition: Surface Chemistry, Film Growth and Electrical Properties
原子层沉积的原位探测:表面化学、薄膜生长和电性能
- 批准号:
0408554 - 财政年份:2004
- 资助金额:
$ 23万 - 项目类别:
Continuing Grant
Diffusion in Crystalline Ice Measured Using Laser Resonant Desorption Techniques
使用激光共振解吸技术测量结晶冰的扩散
- 批准号:
9905812 - 财政年份:1999
- 资助金额:
$ 23万 - 项目类别:
Continuing Grant
Pulmonary Exchange of Nitric Oxide: A Quantitative Description
一氧化氮的肺部交换:定量描述
- 批准号:
9619340 - 财政年份:1997
- 资助金额:
$ 23万 - 项目类别:
Standard Grant
Surface and Bulk Diffusion on Single-Crystal Ice and Acid Hydrate Multilayers
单晶冰和酸水合物多层膜上的表面和体扩散
- 批准号:
9528473 - 财政年份:1996
- 资助金额:
$ 23万 - 项目类别:
Standard Grant
U.S.-Japan Cooperative Research: Atomic Layer Processing of Silicon
美日合作研究:硅原子层加工
- 批准号:
9218342 - 财政年份:1993
- 资助金额:
$ 23万 - 项目类别:
Standard Grant
Presidential Young Investigator Award: Studies of Time - Dependent Fundamental Surface Phenomena.
总统青年研究员奖:时间依赖性基本表面现象的研究。
- 批准号:
9296105 - 财政年份:1992
- 资助金额:
$ 23万 - 项目类别:
Continuing Grant
相似国自然基金
Frontiers of Environmental Science & Engineering
- 批准号:51224004
- 批准年份:2012
- 资助金额:20.0 万元
- 项目类别:专项基金项目
Chinese Journal of Chemical Engineering
- 批准号:21224004
- 批准年份:2012
- 资助金额:20.0 万元
- 项目类别:专项基金项目
Chinese Journal of Chemical Engineering
- 批准号:21024805
- 批准年份:2010
- 资助金额:20.0 万元
- 项目类别:专项基金项目
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