FASEB Summer Conference: Ubiquitin and Intracellular Protein Degradation to be held July 31- Aug. 5, 1999, in Saxton's River, VT.

FASEB 夏季会议：泛素和细胞内蛋白质降解将于 1999 年 7 月 31 日至 8 月 5 日在佛蒙特州萨克斯顿河举行。

• 批准号: 9904915
• 负责人: Cecile Pickart
• 金额: $ 0.48万
• 依托单位: Federation of Amer Societies For Exper Biology
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9904915&HistoricalAwards=false
• 关键词: FASEB; Summer; Conference; Ubiquitin; Intracellular

PickartThe conference "Ubiquitin and Intracellular Protein Degradation" will be held from July 31 through August 5, 1999, at the Conference Center of the Vermont Academy in Saxton's River, VT. This meeting is sponsored by the Federation of the American Societies for Experimental Biology (FASEB). It has been held biennially since 1989. It is the only regularly-held international meeting devoted to the biology and biochemistry of ubiquitin. This award provides partial funding for the 1999 conference.The conserved protein ubiquitin is essential in eukaryotes. The biological functions of ubiquitin are mediated by its covalent attachment, through its C-terminal carboxyl group, to lysine residues of cellular proteins. The best-understood function of ubiquitin is that of a signal which targets proteins for ATP-dependent degradation by the 26S proteasome. In this novel proteolytic pathway, substrate selection and the chemical catalysis of substrate hydrolysis are carried out by separate enzymes, allowing diverse substrates to be recognized and degraded with high selectivity and efficiency. The proteasome is the paradigmatic example of a universally distributed set of ATP-dependent proteases which feature sequestered active sites and a necessity for the coupling of substrate unfolding to proteolysis. By setting the levels of key regulatory proteins, the ubiquitin--proteasome degradation pathway controls fundamental intracellular processes, including the progression of the cell cycle. Besides ubiquitin, eukaryotes possess a family of ubiquitin-like proteins which undergo a metabolism parallel to, but distinct from, that of ubiquitin. These molecules appear to function as covalent signals which target their substrates to specific locations within the cell. The presentations and discussions in the 1999 conference will substantially advance the understanding of the functions of ubiquitin and its homologs.

会议“泛素和细胞内蛋白质降解”将于1999年7月31日至8月5日在佛蒙特州萨克斯顿河佛蒙特学院会议中心举行。这次会议是由美国实验生物学学会联合会（FASEB）主办的。自1989年以来每两年举行一次。它是唯一定期举行的专门讨论泛素生物学和生物化学的国际会议。该奖项为1999年的会议提供了部分资金。在真核生物中保守的蛋白质泛素是必不可少的。泛素的生物学功能是通过其C-末端羧基与细胞蛋白质的赖氨酸残基共价连接而介导的。泛素的最佳理解功能是作为一种信号，通过26 S蛋白酶体靶向蛋白质进行ATP依赖性降解。在这种新的蛋白水解途径中，底物选择和底物水解的化学催化由不同的酶进行，允许以高选择性和效率识别和降解不同的底物。蛋白酶体是一组普遍分布的ATP依赖性蛋白酶的典型例子，其特征是隔离的活性位点以及底物解折叠与蛋白质水解偶联的必要性。通过设定关键调节蛋白的水平，泛素-蛋白酶体降解途径控制基本的细胞内过程，包括细胞周期的进展。除了泛素，真核生物还拥有一个泛素样蛋白家族，其代谢与泛素平行，但又不同。这些分子似乎起共价信号的作用，将其底物靶向细胞内的特定位置。在1999年会议上的介绍和讨论将大大推进泛素及其同系物的功能的理解。