Acquisition of Mass Spectrometers for a University Facility

该奖项来自化学研究仪器和设施（CRIF）和主要研究仪器（MRI）项目，将帮助加州大学河滨分校化学系获得一台质谱仪。该设备将加强许多领域的研究，包括1)昆虫学和神经科学与肽和蛋白质信号分子的生物化学有关，特别是毒液毒素的鉴定和表征；2)参与调节昆虫蜕皮的激素；3)蛋白酶体酶复合物对变性蛋白的分离和裂解机制的生化研究；3)双功能催化化学：通过分子内lewis酸活化增强亲核催化剂；4)定义明确的高维单体、低聚物和聚合物的表征；5)蛋白质中氨基酸侧链交换的化学过程；6)具有重要生物医学意义的天然产物的合成、结构和生物学研究；7)肝素与肽的相互作用；8)硫化学：富勒烯和低聚富勒烯；9)植物低氧胁迫应答相关基因产物的鉴定；10)环境毒理学：肝细胞核因子4相关肽的鉴定；11)不同DNA和RNA结构的表征；12)鉴定p21激活的蛋白激酶g-PAK在体内磷酸化的蛋白。质谱（MS）是一种用于探测内部结构细节和获得大量有机、生物有机和有机金属分子的分子组成的技术。

This award from the Chemistry Research Instrumentation and Facilities (CRIF) and Major Research Instrumentation (MRI) Programs will assist the Department of Chemistry at the University of California in Riverside acquire a Mass Spectrometer. This equipment will enhance research in a number of areas including 1) entomology and neurosciences pertaining to the biochemistry of peptide and protein signaling molecules, specifically the identification and characterization of venom toxins; 2) hormones involved in regulation of insect ecdysis; 3) biochemical studies of the mechanism by which the proteasome enzyme complex sequesters and cleaves denatured proteins; 3) the chemistry of bifunctional catalysis: enhancing nucleophilic catalysts by intramolecular lewis acid activation; 4) characterization of well-defined and high-dimensional monomers, oligomers & polymers; 5) the chemistry of amino acid sidechain exchange in proteins; 6) synthesis, structural and biological studies of biomedically significant natural products; 7) interaction of heparin with peptides; 8) sulfur chemistry: fullerenes & oligomeric fullerenes; 9) identification of gene products involved in plant responses to low oxygen stress; 10) environmental toxicology: identification of peptides associated with hepatocyte nuclear factor 4; 11) characterization of alternative DNA and RNA structures; 12) identification of proteins phosphorylated in vivo by the p21-activated protein kinase g-PAK. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules.