Acquisition of Mass Spectrometers for a University Facility

化学研究仪器和设施（CRIF）和主要研究仪器（MRI）计划的这一奖项将帮助加州大学滨江分校化学系获得质谱仪。 这一设备将加强若干领域的研究，包括：（1）与肽和蛋白质信号分子的生物化学有关的昆虫学和神经科学，特别是毒液毒素的鉴定和表征;（2）与昆虫蜕皮调节有关的激素;（3）蛋白酶体酶复合物螯合和切割变性蛋白质的机制的生物化学研究; 3）双功能催化化学：通过分子内刘易斯酸活化增强亲核催化剂; 4）明确定义的和高维单体、低聚物的表征; 5）蛋白质中氨基酸侧链交换的化学; 6）具有生物医学意义的天然产物的合成、结构和生物学研究&; 7）肝素与肽的相互作用; 8）硫化学：富勒烯低聚富勒烯; 9）鉴定植物对低氧胁迫反应的基因产物; 10）环境毒理学：鉴定与肝细胞核因子4相关的肽; 11）DNA和RNA替代结构的表征&; 12）通过p21活化的蛋白激酶g-PAK鉴定体内磷酸化的蛋白质。 质谱（MS）是一种用于探测紧密结构细节并获得大量有机、生物有机和有机金属分子的分子组成的技术。

This award from the Chemistry Research Instrumentation and Facilities (CRIF) and Major Research Instrumentation (MRI) Programs will assist the Department of Chemistry at the University of California in Riverside acquire a Mass Spectrometer. This equipment will enhance research in a number of areas including 1) entomology and neurosciences pertaining to the biochemistry of peptide and protein signaling molecules, specifically the identification and characterization of venom toxins; 2) hormones involved in regulation of insect ecdysis; 3) biochemical studies of the mechanism by which the proteasome enzyme complex sequesters and cleaves denatured proteins; 3) the chemistry of bifunctional catalysis: enhancing nucleophilic catalysts by intramolecular lewis acid activation; 4) characterization of well-defined and high-dimensional monomers, oligomers & polymers; 5) the chemistry of amino acid sidechain exchange in proteins; 6) synthesis, structural and biological studies of biomedically significant natural products; 7) interaction of heparin with peptides; 8) sulfur chemistry: fullerenes & oligomeric fullerenes; 9) identification of gene products involved in plant responses to low oxygen stress; 10) environmental toxicology: identification of peptides associated with hepatocyte nuclear factor 4; 11) characterization of alternative DNA and RNA structures; 12) identification of proteins phosphorylated in vivo by the p21-activated protein kinase g-PAK. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules.