Acquisition of Mass Spectrometers for a University Facility

为大学设施购置质谱仪

• 批准号: 9977714
• 负责人: Christopher Switzer
• 金额: $ 18.75万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-10-01 至 2001-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9977714&HistoricalAwards=false
• 关键词: Acquisition; Mass; Spectrometers; University; Facility

This award from the Chemistry Research Instrumentation and Facilities (CRIF) and Major Research Instrumentation (MRI) Programs will assist the Department of Chemistry at the University of California in Riverside acquire a Mass Spectrometer. This equipment will enhance research in a number of areas including 1) entomology and neurosciences pertaining to the biochemistry of peptide and protein signaling molecules, specifically the identification and characterization of venom toxins; 2) hormones involved in regulation of insect ecdysis; 3) biochemical studies of the mechanism by which the proteasome enzyme complex sequesters and cleaves denatured proteins; 3) the chemistry of bifunctional catalysis: enhancing nucleophilic catalysts by intramolecular lewis acid activation; 4) characterization of well-defined and high-dimensional monomers, oligomers & polymers; 5) the chemistry of amino acid sidechain exchange in proteins; 6) synthesis, structural and biological studies of biomedically significant natural products; 7) interaction of heparin with peptides; 8) sulfur chemistry: fullerenes & oligomeric fullerenes; 9) identification of gene products involved in plant responses to low oxygen stress; 10) environmental toxicology: identification of peptides associated with hepatocyte nuclear factor 4; 11) characterization of alternative DNA and RNA structures; 12) identification of proteins phosphorylated in vivo by the p21-activated protein kinase g-PAK. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules.

化学研究仪器和设施（CRIF）和主要研究仪器（MRI）计划的这一奖项将帮助加州大学滨江分校化学系获得质谱仪。 这一设备将加强若干领域的研究，包括：（1）与肽和蛋白质信号分子的生物化学有关的昆虫学和神经科学，特别是毒液毒素的鉴定和表征;（2）与昆虫蜕皮调节有关的激素;（3）蛋白酶体酶复合物螯合和切割变性蛋白质的机制的生物化学研究; 3）双功能催化化学：通过分子内刘易斯酸活化增强亲核催化剂; 4）明确定义的和高维单体、低聚物的表征; 5）蛋白质中氨基酸侧链交换的化学; 6）具有生物医学意义的天然产物的合成、结构和生物学研究&; 7）肝素与肽的相互作用; 8）硫化学：富勒烯低聚富勒烯; 9）鉴定植物对低氧胁迫反应的基因产物; 10）环境毒理学：鉴定与肝细胞核因子4相关的肽; 11）DNA和RNA替代结构的表征&; 12）通过p21活化的蛋白激酶g-PAK鉴定体内磷酸化的蛋白质。 质谱（MS）是一种用于探测紧密结构细节并获得大量有机、生物有机和有机金属分子的分子组成的技术。