Acquisition of a 600 MHz NMR for a Campus-Wide Facility

为校园范围内的设施采购 600 MHz NMR

• 批准号: 0320922
• 负责人: Christopher Switzer
• 金额: $ 65.93万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2006-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0320922&HistoricalAwards=false
• 关键词: Acquisition; 600; MHz; NMR; Campus

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at the University of California in Riverside will acquire a high field (600 MHz) NMR Spectrometer. This equipment will enable researchers to carry out studies on a) the effects of disulfide bonds on peptide hormones; b) the dynamics of cis/trans isomerization of peptide bonds; c) interactions of peptides with heparin; d) allosteric transitions of insulin; and e) the structure of DNA pentaplexes. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in biochemistry.

有了这项来自主要研究仪器（MRI）计划的奖项，位于滨江的加州大学化学系将获得一台高场（600 MHz）NMR光谱仪。该设备将使研究人员能够进行以下研究：a）二硫键对肽激素的影响; B）肽键顺式/反式异构化的动力学; c）肽与肝素的相互作用; d）胰岛素的变构转换;以及e）DNA五链体的结构。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对生物化学产生影响。