Function and transcriptional regulation of a plant detoxification program

植物解毒程序的功能和转录调控

• 批准号: 137317980
• 负责人: Professorin Dr. Christiane Gatz
• 金额: --
• 依托单位: Abteilung Molekularbiologie und Physiologie der Pflanze
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/137317980?language=en
• 关键词: Function; transcriptional; regulation; plant; detoxification

Plants are challenged by toxic chemicals that are either released by man, neighboring plants or pathogenic microbes. Moreover, endogenous reactive molecules accumulate under conditions of oxidative stress generated under adverse abiotic conditions or pathogen attack. Inactivation and elimination of harmful xenobiotic or endogenous substances is facilitated by an inducible set of detoxifying enzymes and transporters. Activation of at least part of this detoxification program can be triggered by xenobiotics like INA (2,6-dichloroisonicotinic acid), 2,4-D (2,4-dichlorophenoxyacetic acid) and TIBA (2,4,6-triiodobenzoic acid), as well as by high levels of salicylic acid. We have shown that the TGA family of bZIP transcription factors and the interacting GRAS protein SCL14 are important for this activation (Fode et al., 2008). We aim to obtain further insight into SCL14/TGA-dependent transcriptional control mechanisms in chemically stressed plants and to determine the importance of this pathway for the restriction of disease or stress symptoms.

植物受到人类、邻近植物或病原微生物释放的有毒化学物质的挑战。此外，内源性活性分子在不利的非生物条件或病原体攻击下产生的氧化应激条件下积累。有害的外源或内源性物质的失活和消除是由一组可诱导的解毒酶和转运体促进的。至少部分解毒程序的激活可以由INA（2,6-二氯异烟酸）、2,4-d（2,4-二氯苯氧乙酸）和TIBA（2,4,6-三碘苯甲酸）等外源药物以及高水平的水杨酸触发。我们已经证明，bZIP转录因子的TGA家族和相互作用的GRAS蛋白SCL14对这种激活很重要（Fode et al., 2008）。我们的目标是进一步了解化学胁迫植物中依赖于SCL14/ tga的转录控制机制，并确定这一途径对限制疾病或胁迫症状的重要性。