Function and transcriptional regulation of a plant detoxification program

植物受到人类、邻近植物或病原微生物释放的有毒化学物质的挑战。此外，内源性反应分子在不利的非生物条件或病原体攻击下产生的氧化应激条件下积累。一组可诱导的解毒酶和转运蛋白促进了有害的外源性或内源性物质的灭活和消除。至少部分解毒程序的激活可以由异生物质如INA（2，6-二氯异烟酸），2，4-D（2，4-二氯苯氧乙酸）和TIBA（2，4，6-三碘苯甲酸）以及高水平的水杨酸触发。我们已经表明bZIP转录因子的TGA家族和相互作用的GRAS蛋白SCL 14对于这种激活是重要的（Fode等人，2008年）。我们的目标是获得进一步的了解SCL 14/TGA依赖的转录控制机制在化学应激植物，并确定这一途径的重要性，限制疾病或应激症状。

Plants are challenged by toxic chemicals that are either released by man, neighboring plants or pathogenic microbes. Moreover, endogenous reactive molecules accumulate under conditions of oxidative stress generated under adverse abiotic conditions or pathogen attack. Inactivation and elimination of harmful xenobiotic or endogenous substances is facilitated by an inducible set of detoxifying enzymes and transporters. Activation of at least part of this detoxification program can be triggered by xenobiotics like INA (2,6-dichloroisonicotinic acid), 2,4-D (2,4-dichlorophenoxyacetic acid) and TIBA (2,4,6-triiodobenzoic acid), as well as by high levels of salicylic acid. We have shown that the TGA family of bZIP transcription factors and the interacting GRAS protein SCL14 are important for this activation (Fode et al., 2008). We aim to obtain further insight into SCL14/TGA-dependent transcriptional control mechanisms in chemically stressed plants and to determine the importance of this pathway for the restriction of disease or stress symptoms.