Interfacial Compositions and Polypeptide Topologies in Surfactant Assemblies: New Applications of the Chemical Trapping Method

有了这个新的奖项，有机和大分子化学项目将继续支持新泽西州新不伦瑞克市罗格斯大学化学系劳伦斯·s·罗姆斯特德博士的工作。Romsted博士的工作重点是了解在胶束、微乳液和囊泡的油水界面上发生的物质浓度和化学反应。做这项工作的部分基本原理是了解抗氧化剂在这类界面上的行为。脂质过氧化作用，由于抗氧化剂的存在而减少，发生在许多疾病中，也与食物变质时异味的形成有关。Romsted开发了一种研究油水界面上分子的浓度和取向的方法，使用聚集体结合的arenediazonium离子作为弱碱性亲核试剂的陷阱，如水、羟基、卤化物和羧酸离子、肽的N和O原子以及离子和非离子表面活性剂的头基。他使用了多种方法来探测界面区域，包括核磁共振、紫外/可见光谱、荧光、红外和EPR，并表明他的捕获方法提供了其他方法无法获得的补充，有时甚至是独特的信息。

With this renewal award, the Organic and Macromolecular Chemistry Program is continuing support for the work of Dr. Laurence S. Romsted in the Department of Chemistry at Rutgers University in New Brunswick, NJ. Dr. Romsted's work is focused on understanding the species concentrations and chemical reactions that take place at the oil-water interface of micelles, microemulsions, and vesicles. Part of the rationale for doing the work is to understand the behavior of antioxidants at interfaces of this type. Lipid peroxidation, which is decreased by the presence of antioxidants, takes place in a number of diseases and is also involved in the formation of off-flavors and odors in foods as they spoil.Dr. Romsted has developed a method for studying the concentrations and orientations of molecules at oil-water interfaces using aggregate bound arenediazonium ion as a trap for weakly basic nucleophiles, such as water, hydroxyl group, halide and carboxylate ions, the N and O atoms of peptides, and the head groups of ionic and nonionic surfactants. He has used a variety of methods to probe the interfacial region, including NMR, UV/Vis spectroscopy, fluorescence, IR, and EPR, and shown that his trapping method gives complementary and sometimes unique information not available by the other methods.