Statistics in Drug Discovery

药物发现统计

• 批准号: 0072809
• 负责人: Jacqueline Hughes-Oliver
• 金额: $ 3.84万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2002-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0072809&HistoricalAwards=false
• 关键词: Statistics; Drug; Discovery

Students who are supported solely by industry are typically so involved with solving the company's daily problems that they do not have opportunities for conducting research to aid their understanding of the basic problems encountered. This project provides funding for two students so that half their time will be devoted to research on new opportunities identified through company projects and the remaining time will be devoted to working on the company's daily problems. The company identified for this project is Glaxo Wellcome (GW), with Dr. S. Stanley Young serving as industry mentor. Specific goals include developing methods for: (a) variable selection in the context of pooled data on compound potency; (b) using pooled data for elucidating the relationship between the chemical structural features of individual compounds and the probabilities that the compound will be biologically potent or will restrict biological potency; and (c) predicting the potencyof an individual compound solely based on its chemical structural features.Students will gain experience in formulating research problems, evaluating project impacts on the company's operation and on scientific research, and making oral and written presentations to individuals from different disciplines. This proposal will also impact GW's operations. Because company scientists are involved in the program, the procedures developed will be more suitable for their applications and there is a potential for the company to invent profitable products resulting from these studies. This GOALI project is jointly supported by the MPS Office of Multidisciplinary Activities (OMA) and the Division of Mathematical Sciences (DMS).

那些完全由行业支持的学生通常都在忙于解决公司的日常问题，以至于他们没有机会进行研究来帮助他们理解所遇到的基本问题。该项目为两名学生提供资金，以便他们一半的时间将用于研究通过公司项目确定的新机会，其余时间将用于解决公司的日常问题。该项目选定的公司是葛兰素惠康（GW），由S. Stanley Young博士担任行业导师。具体目标包括开发以下方法：(a)在化合物效价汇总数据的背景下进行变量选择；(b)使用汇总数据阐明单个化合物的化学结构特征与该化合物具有生物效力或限制生物效力的可能性之间的关系；(c)仅根据其化学结构特征预测单个化合物的效力。学生将获得制定研究问题，评估项目对公司运营和科研的影响，以及向不同学科的个人进行口头和书面报告的经验。这一提议也将影响GW的运营。由于公司的科学家参与了该项目，开发的程序将更适合他们的应用，并且公司有可能从这些研究中发明有利可图的产品。该GOALI项目由MPS多学科活动办公室（OMA）和数学科学司（DMS）联合支持。