Conference: FASEB RNA Sorting,Transport, and Localization in Development; to be held in Snowmass, CO, June 10-15, 2000

会议：FASEB RNA 分选、运输和定位开发；

• 批准号: 0076176
• 负责人: Laurence Etkin
• 金额: $ 0.5万
• 依托单位: Federation of Amer Societies For Exper Biology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0076176&HistoricalAwards=false
• 关键词: Conference; FASEB; RNA; Sorting; Transport

0076176EtkinThe importance of RNA sorting, targeted mRNA transport, and local protein synthesis has become evident as a result of the convergence of information from studies focusing on a variety of molecular, cellular and developmental questions. Through these diverse efforts, it is now clear that the targeting of mRNAs to particular intracellular locations plays a key role in biological processes that include the establishment of oocyte polarity, early embryonic differentiation, somatic cell polarization and function, synapse growth, and plasticity in the vertebrate nervous system. The goal of the proposed conference is to bring together researchers with a wide range of backgrounds and perspectives who study RNA sorting and localization using a variety of experimental approaches. It is the intent to explore common themes and questions including: (i) The role of RNA localization in the establishment of embryonic cell lineages and axial polarity in invertebrates and vertebrates; (ii) the nature of the cis-acting signals and trans-acting factors that target mRNAs to particular intracellular locations; (iii) the nature of the delivery systems that are involved; (iv) the mechanisms that anchor localized mRNAs once they research their proper destinations; (v) definition of the nature and number of different destinations that reside within individual cell types; (vi) the extent to which mRNA translocation and sorting is regulated by extracellular and intracellular signaling processes; (vii) the mechanisms involved in transport of RNAs from the nucleus to the cytoplasm and in some cases from the cytoplasm to the nucleus; and (viii) the multiple ways in which RNA sorting plays a role in cellular function such as translational regulation.

0076176 Etkin RNA分选、靶向mRNA转运和局部蛋白质合成的重要性已经变得显而易见，这是由于集中于各种分子、细胞和发育问题的研究的信息的汇聚。 通过这些不同的努力，现在清楚的是，靶向特定的细胞内位置的mRNA在生物过程中起着关键作用，包括卵母细胞极性的建立，早期胚胎分化，体细胞极化和功能，突触生长和可塑性在脊椎动物神经系统。 拟议会议的目标是汇集具有广泛背景和观点的研究人员，他们使用各种实验方法研究RNA分选和定位。 它的目的是探讨共同的主题和问题，包括：（一）在无脊椎动物和脊椎动物的胚胎细胞谱系和轴向极性的建立RNA定位的作用;（二）顺式作用的信号和反式作用因子的性质，目标mRNA的特定细胞内位置;（三）性质的交付系统所涉及的;（iv）一旦它们研究其适当的目的地，锚定位mRNA的机制;（v）存在于个体细胞类型内的不同目的地的性质和数量的定义;（vi）mRNA易位和分选受细胞外和细胞内信号传导过程调节的程度;（vii）参与RNA从细胞核到细胞质以及在某些情况下从细胞质到细胞核的转运的机制;以及（viii）RNA分选在细胞功能如翻译调节中发挥作用的多种方式。