Molecular Genetics of Cell Patterning in the Arabidopsis Root Epidermis
拟南芥根表皮细胞模式的分子遗传学
基本信息
- 批准号:0077900
- 负责人:
- 金额:$ 37.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-08-01 至 2004-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
0779000SchiefelbeinAll multicellular organisms must solve a fundamental problem during their development: How to generate different cell types from a single original cell? The research conducted in this project is designed to address this question and help uncover the molecular mechanisms used by living things to produce distinct cell types in appropriate patterns.This project employs a simple model system for studying cell fate specification; the formation of the root epidermis in the flowering plant Arabidopsis thaliana. The Arabidopsis root epidermis is exceptional because its two cell types are produced in a predictable position-dependent fashion. Furthermore, the root epidermis is formed continuously as the root grows, so the formation of the epidermal cells can be easily followed at all stages of development. Finally, plants that lack either root epidermal cell type are viable, enabling sophisticated genetic experimentation.In recent studies, four genes encoding putative transcriptional regulators (named TTG, WER, GL2, and CPC) have been found to control the patterning of the two epidermal cell types. It appears that the normal patterning of the cell types is due the appropriate production, distribution, and interaction of these regulators during root development. The research in the present project period is intended to: (1) more clearly define the interactions between the WER regulator and each of the other factors, (2) illuminate the functional relationship between the WER and a closely-related transcriptional regulator affecting shoot epidermis cell fate, and (3) uncover new regulators of epidermal cell patterning. The results of these studies are expected to provide a greater understanding of the molecules and mechanisms employed by Arabidopsis and multicellular organisms in general, to generate and regulate cellular diversity during development
0779000 Schiefelbein所有多细胞生物在发育过程中都必须解决一个基本问题:如何从单个原始细胞中产生不同的细胞类型? 本项目的研究旨在解决这一问题,并帮助揭示生物以适当模式产生不同细胞类型的分子机制。本项目采用一个简单的模型系统来研究细胞命运的规范,即开花植物拟南芥根表皮的形成。 拟南芥根表皮是例外,因为它的两种细胞类型是在一个可预测的位置依赖的方式产生。 此外,根表皮随着根的生长而连续形成,因此在发育的所有阶段都可以容易地跟踪表皮细胞的形成。 最后,缺乏任何一种根表皮细胞类型的植物都是可行的,使得复杂的遗传实验成为可能。在最近的研究中,已经发现编码假定的转录调节因子(命名为TTG、WER、GL2和CPC)的四个基因控制两种表皮细胞类型的模式。 看来,正常模式的细胞类型是由于适当的生产,分布和相互作用,这些监管机构在根的发展。 本项目期间的研究旨在:(1)更清楚地定义WER调节器和其他每个因子之间的相互作用,(2)阐明WER和影响芽表皮细胞命运的密切相关的转录调节器之间的功能关系,以及(3)发现新的表皮细胞模式调节器。 这些研究的结果有望为拟南芥和多细胞生物在发育过程中产生和调节细胞多样性的分子和机制提供更好的理解
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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John Schiefelbein其他文献
Genetic and genomic dissection of a cell specification pathway in <em>Arabidopsis</em>
- DOI:
10.1016/j.ydbio.2011.05.056 - 发表时间:
2011-08-01 - 期刊:
- 影响因子:
- 作者:
John Schiefelbein - 通讯作者:
John Schiefelbein
On scientific mentoring and scientific teaching: A tribute to Viktor Hamburger
- DOI:
10.1016/j.ydbio.2006.04.069 - 发表时间:
2006-07-01 - 期刊:
- 影响因子:
- 作者:
John Schiefelbein;Su-Hwan Kwak;Christine Bernhardt;Christa Barron;Marissa Simon - 通讯作者:
Marissa Simon
Negative feedback regulation of <em>GLABRA1</em> contributes to epidermal cell patterning in the Arabidopsis root
- DOI:
10.1016/j.bbrc.2024.150869 - 发表时间:
2024-12-10 - 期刊:
- 影响因子:
- 作者:
Sang-Kee Song;Dong Won Jeong;Yun Ju Kim;John Schiefelbein;Myeong Min Lee - 通讯作者:
Myeong Min Lee
Nitrate regulation of lateral root and root hair development in plants
- DOI:
https://doi.org/10.1093/jxb/erz536 - 发表时间:
2019 - 期刊:
- 影响因子:
- 作者:
Bohan Liu;Junyu Wu;Shuaiqi Yang;John Schiefelbein;Yinbo Gan - 通讯作者:
Yinbo Gan
A gene regulatory network for cell-type patterning in the <em>Arabidopsis</em> root epidermis
- DOI:
10.1016/j.ydbio.2006.04.068 - 发表时间:
2006-07-01 - 期刊:
- 影响因子:
- 作者:
John Schiefelbein;Su-Hwan Kwak;Christine Bernhardt;Christa Barron;Marissa Simon - 通讯作者:
Marissa Simon
John Schiefelbein的其他文献
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{{ truncateString('John Schiefelbein', 18)}}的其他基金
Collaborative Research: EAGER/Tools4Cells: Translating single cell data into an ultra-high resolution spatial map using fluorescent marker genes
合作研究:EAGER/Tools4Cells:使用荧光标记基因将单细胞数据转化为超高分辨率空间图
- 批准号:
2218235 - 财政年份:2022
- 资助金额:
$ 37.5万 - 项目类别:
Standard Grant
Roots and Root Hairs: Comparative Molecular Studies Across Land Plants
根和根毛:陆地植物的比较分子研究
- 批准号:
1444400 - 财政年份:2015
- 资助金额:
$ 37.5万 - 项目类别:
Continuing Grant
Molecular Basis of Positional Signaling in Arabidopsis Root Epidermal Development
拟南芥根表皮发育中位置信号传导的分子基础
- 批准号:
1121602 - 财政年份:2011
- 资助金额:
$ 37.5万 - 项目类别:
Continuing Grant
Positional Signaling in Arabidopsis Root Epidermis Development
拟南芥根表皮发育中的位置信号
- 批准号:
0744599 - 财政年份:2008
- 资助金额:
$ 37.5万 - 项目类别:
Continuing Grant
Arabidopsis 2010: Constructing and Analyzing a Model Gene Regulatory Network
拟南芥 2010:构建和分析模型基因调控网络
- 批准号:
0723493 - 财政年份:2008
- 资助金额:
$ 37.5万 - 项目类别:
Continuing Grant
FASEB Conference on Mechanisms in Plant Development; August 7-11, 2004; Saxtons, VT
FASEB 植物发育机制会议;
- 批准号:
0415501 - 财政年份:2004
- 资助金额:
$ 37.5万 - 项目类别:
Standard Grant
Role of an LRR Receptor-Like Kinase in Root Epidermal Patterning
LRR 受体样激酶在根表皮图案形成中的作用
- 批准号:
0316312 - 财政年份:2003
- 资助金额:
$ 37.5万 - 项目类别:
Continuing Grant
Molecular Genetics of Cell Fate Specification in the Arabidopsis Root Epidermis
拟南芥根表皮细胞命运规范的分子遗传学
- 批准号:
9724149 - 财政年份:1997
- 资助金额:
$ 37.5万 - 项目类别:
Continuing Grant
Molecular Genetics of Root Hair Development in Arabidopsis
拟南芥根毛发育的分子遗传学
- 批准号:
9316409 - 财政年份:1994
- 资助金额:
$ 37.5万 - 项目类别:
Continuing Grant
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