Molecular Basis of Positional Signaling in Arabidopsis Root Epidermal Development

拟南芥根表皮发育中位置信号传导的分子基础

• 批准号: 1121602
• 负责人: John Schiefelbein
• 金额: $ 54万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1121602&HistoricalAwards=false
• 关键词: Molecular; Basis; Positional; Signaling; Arabidopsis

The development of living things is dependent upon communication between different cells and tissues, to ensure that the formation of different parts of the organism occurs in an orderly and coordinated manner. A current challenge in the field of developmental biology is to define the specific signaling molecules that are used for this communication and to understand how they function. In this project, a newly discovered group of signaling molecules, known as germin-like proteins (GLPs), will be analyzed for their role in the formation and patterning of cells and tissues of plants. This work will take advantage of the Arabidopsis root as a simple and effective model organ for analyzing the molecular and genetic control of development by specific molecules. The GLPs will be tested for their involvement in the development of different cells and tissues, and for their interaction with specific receptor molecules. The results from this project are expected to provide new insights into the ways that cells and tissues communicate during development. Furthermore, this project has been designed to provide a rich interdisciplinary training experience for undergraduates, graduate students, and postdoctoral fellows, and it will establish a summer research program at the University of Michigan for students from Long Island University. In the long term, this project is expected to enable the rational design of plant structures to enhance plant productivity and growth under a variety of environmental conditions.

生物的发育依赖于不同细胞和组织之间的交流，以保证机体不同部位的形成有序、协调地进行。发育生物学领域目前面临的一个挑战是确定用于这种交流的特定信号分子并了解它们的功能。在这个项目中，一组新发现的信号分子，被称为发芽样蛋白（GLPs），将被分析它们在植物细胞和组织的形成和模式中的作用。本研究将利用拟南芥根作为一个简单有效的模式器官，分析特定分子对发育的分子和遗传控制。glp将被测试是否参与不同细胞和组织的发育，以及它们与特定受体分子的相互作用。这个项目的结果有望为细胞和组织在发育过程中的交流方式提供新的见解。此外，该项目旨在为本科生、研究生和博士后提供丰富的跨学科培训经验，并将为长岛大学的学生在密歇根大学建立一个夏季研究项目。从长远来看，该项目有望实现植物结构的合理设计，以提高植物在各种环境条件下的生产力和生长。