XYZ (Chip): Patterning Flow at the Microscale: Open Architecture Design for Integrated Fluidic Chips

普林斯顿大学Sandra Troian将化学分析和合成的多种功能集成到手持设备中的倡议已经产生了对通过网络阵列传输超小体积液体的有效方法的探索。 我们最近发现了一种非电子现象，这种现象理想地适合在集成电路（IC）表面上构建完整的化学反应器。 开放式结构设计使用基于热的工艺，用于沿着化学微图案表面的选定路径路由和反应纳升至皮升体积的液体沿着。 可以从其设计在尺寸和输出电压上很好地匹配的底层集成芯片主动寻址路径和反应位点。 这种现象依赖于热毛细运输的液体在表面上的结构化的润湿性产生的微图案化的自组装单层。 这种设计不仅在单个芯片上结合了微电子电路功能的优点。 目标是使用片上有源矩阵电路通过寻址单个像素来打开和关闭地下加热元件。 这种用于微体积液体的路由和反应的技术是低电压、低电流且没有移动部件的。这样的反应器设计将找到众多用户，从数字可重构表面通道中流体流动的自动研究到可学习反应序列中复杂混合物的识别-所有这些都在单个芯片上。 该配置允许最终开发用于快速感测和分析体液或空气传播的化学试剂的手表安装设备。 这种集成的“湿”芯片的开发和设计需要对流体输送和晶片集成有高度的基本理解。 该计划结合了几个小组的互补技能，以建立一个强大的实验和理论努力。操纵直线，弯曲和分裂流以及离散液滴的实验技术。微电子电路与开放式结构微流体的集成。从连续和分子的角度对热毛细传输能力的理论理解。该合作包括化学和电气工程，化学和物理。 主要研究人员在吸引和指导各级研究生的多样化群体方面有着良好的记录，其中许多人因其研究项目而获得了部门和全校的奖项。 这些研究人员还位于新泽西的一个地区，那里有许多专门关注新兴生物流体技术的行业。 几家公司已经要求提供拟议芯片的样品，用于生物测定测试。

ABSTRACTCTS-0088774Sandra TroianPrinceton UniversityInitiatives to miniaturize and integrate multiple functionalities for chemical analysis and synthesis into a hand held device have generated a quest for efficient methods to transport ultra small volumes of liquid through networked arrays. We recently discovered a non-electronic phenomenon that ideally lends itself to the construction of a complete chemical reactor on the surface of an integrated circuit (IC). The open architecture design uses a thermally based process for routing and reacting nanoliter to picoliter volumes of liquid along selected pathways of a chemically micropattern surface. The pathways and reaction sites can be actively addressed from an underlying integrated chip whose design is well matched in size and output voltage. The phenomenon relies on thermocapillary transport of liquid on a surface of structured wettability produced by micropatterning a self-assembled monolayer. Not only does this design couple the benefits of microelectronic circuitry functionality on a single chip. The goal is to use on-chip active matrix circuits to switch subsurface heating elements on and off by addressing individual pixels. This proposed technology for routing and reacting microvolumes of liquid is low voltage, low-current and has no moving parts.Such a reactor design will find a multitude of users ranging from automated studies of fluid flow in digitally reconfigurable surface channels to the identification of complex mixtures in learnable reaction sequences - all on a single chip. The configuration allows for the eventual development of wristwatch mounted devices for rapid sensing and analysis of bodily fluids or airborne chemical agents. The development and design of this integrated "wet" chip requires a high degree of fundamental understanding of the fluidic transport and wafer integration. The program combines complementary skills form several groups to build a strong experimental and theoretical effort.Experimental techniques for manipulating rectilinear, bent and split streams as well as discrete droplets.Integration of microelectronic circuitry with open architecture microfluidic.Theoretical understanding of the capabilities of thermocapillary transport from a continuum and molecular viewpoint.The collaboration includes investigators from chemical and electrical engineering, chemistry and physics. The principal investigators have a strong record in attracting and advising a diverse group of graduate students at all levels, many of whom have won departmental and school-wide awards for their research projects. These investigators are also well situated in an area of New Jersey in which there are many industries specifically focused on emerging biofluidic technologies. Several companies have already requested samples of the proposed chip for tests of biological assays.