XYZ (Chip): Patterning Flow at the Microscale: Open Architecture Design for Integrated Fluidic Chips

【摘要】普林斯顿大学桑德拉·特罗安：将化学分析和合成的多种功能小型化和集成到手持设备中的倡议，已经产生了对通过网络阵列传输超小体积液体的有效方法的追求。我们最近发现了一种非电子现象，这种现象非常适合在集成电路（IC）表面构建完整的化学反应器。开放式架构设计采用基于热的工艺，沿着化学微图案表面的选定路径，将纳升到皮升体积的液体进行路由和反应。途径和反应位点可以从底层集成芯片主动寻址，其设计在尺寸和输出电压上很好地匹配。这种现象依赖于液体在自组装单层微图图化产生的结构润湿性表面上的热毛细输送。这种设计不仅在单个芯片上结合了微电子电路功能的优点。目标是使用片上有源矩阵电路通过寻址单个像素来开关地下加热元件。提出的微体积液体布线和反应技术具有低电压、低电流和无运动部件的特点。这样的反应器设计将找到众多用户，从数字可重构表面通道中流体流动的自动研究到可学习反应序列中复杂混合物的识别-所有这些都在单个芯片上。这种配置允许最终开发腕表安装设备，用于快速传感和分析体液或空气传播的化学剂。这种集成“湿”芯片的开发和设计需要对流体传输和晶圆集成有高度的基本理解。该计划结合了几个小组的互补技能，以建立一个强大的实验和理论努力。操纵直线、弯曲和分裂流以及离散液滴的实验技术。微电子电路与开放式微流控的集成。从连续体和分子的角度对热毛细输送能力的理论认识。这项合作包括来自化学和电气工程、化学和物理的研究人员。主要研究人员在吸引和指导不同层次的研究生群体方面有着良好的记录，其中许多人因其研究项目获得了院系和全校的奖项。这些研究人员也位于新泽西州的一个地区，那里有许多专门关注新兴生物流体技术的行业。有几家公司已经要求获得拟议芯片的样本，用于生物分析测试。

ABSTRACTCTS-0088774Sandra TroianPrinceton UniversityInitiatives to miniaturize and integrate multiple functionalities for chemical analysis and synthesis into a hand held device have generated a quest for efficient methods to transport ultra small volumes of liquid through networked arrays. We recently discovered a non-electronic phenomenon that ideally lends itself to the construction of a complete chemical reactor on the surface of an integrated circuit (IC). The open architecture design uses a thermally based process for routing and reacting nanoliter to picoliter volumes of liquid along selected pathways of a chemically micropattern surface. The pathways and reaction sites can be actively addressed from an underlying integrated chip whose design is well matched in size and output voltage. The phenomenon relies on thermocapillary transport of liquid on a surface of structured wettability produced by micropatterning a self-assembled monolayer. Not only does this design couple the benefits of microelectronic circuitry functionality on a single chip. The goal is to use on-chip active matrix circuits to switch subsurface heating elements on and off by addressing individual pixels. This proposed technology for routing and reacting microvolumes of liquid is low voltage, low-current and has no moving parts.Such a reactor design will find a multitude of users ranging from automated studies of fluid flow in digitally reconfigurable surface channels to the identification of complex mixtures in learnable reaction sequences - all on a single chip. The configuration allows for the eventual development of wristwatch mounted devices for rapid sensing and analysis of bodily fluids or airborne chemical agents. The development and design of this integrated "wet" chip requires a high degree of fundamental understanding of the fluidic transport and wafer integration. The program combines complementary skills form several groups to build a strong experimental and theoretical effort.Experimental techniques for manipulating rectilinear, bent and split streams as well as discrete droplets.Integration of microelectronic circuitry with open architecture microfluidic.Theoretical understanding of the capabilities of thermocapillary transport from a continuum and molecular viewpoint.The collaboration includes investigators from chemical and electrical engineering, chemistry and physics. The principal investigators have a strong record in attracting and advising a diverse group of graduate students at all levels, many of whom have won departmental and school-wide awards for their research projects. These investigators are also well situated in an area of New Jersey in which there are many industries specifically focused on emerging biofluidic technologies. Several companies have already requested samples of the proposed chip for tests of biological assays.