RUI: Fabrication, Characterization and Applications of New Separation Media

RUI：新型分离介质的制造、表征和应用

• 批准号: 0094983
• 负责人: Joseph Pesek
• 金额: $ 31万
• 依托单位: San Jose State University Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-15 至 2005-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0094983&HistoricalAwards=false
• 关键词: RUI; Fabrication; Characterization; Applications; New

Professor Joseph Pesek of San Jose State University is sponsored by the Analytical and Surface Chemistry Program via a RUI grant for research on fabrication, characterization and applications of new separation media. The research will lead to the development of new substrates for HPLC, capillary electrophoresis (CE), capillary electrochromatography (CEC), and solid phase microextraction (SPME) for the purpose of improved separations. The first part of the work focuses on chemical modification of silica and other oxide surfaces with organic moieties, especially alkynes. Chemical modification will also be achieved with liquid crystal compounds. The second part focuses on etching processes for the purpose of increased surface area, and subsequent application of these materials to open tube CEC separations (OTCEC) and SPME configurations. OTCEC will be developed for improved separation of proteins, peptides and pharmaceuticals.The ability to separate biological compounds is of great importance in medical research and genomics, as well as in chemical and pharmaceutical industry. Exposure to this work will enable San Jose students (many of whom are from under-represented groups) to enter technical positions in these areas of national need.

圣何塞州立大学的Joseph Pesek教授通过RUI资助获得了分析和表面化学项目的赞助，用于研究新型分离介质的制造、表征和应用。 该研究将导致开发新的HPLC，毛细管电泳（CE），毛细管电色谱（CEC）和固相微萃取（SPME）的基板，以改善分离的目的。 第一部分的工作重点是化学改性的二氧化硅和其他氧化物表面的有机部分，特别是炔。 化学修饰也将用液晶化合物实现。 第二部分着重于蚀刻工艺的目的，增加表面积，以及随后的应用这些材料的开管CEC分离（OTCEC）和SPME配置。 OTCEC将用于蛋白质、多肽和药物的分离，分离生物化合物的能力在医学研究和基因组学以及化学和制药工业中具有重要意义。 接触这项工作将使圣何塞学生（其中许多人来自代表性不足的群体）进入国家需要的这些领域的技术职位。