The Synthesis of Novel Chemically Bonded Stationary Phases for Gas and High Pressure Liquid Chromatography

用于气相和高压液相色谱的新型化学键固定相的合成

• 批准号: 8814849
• 负责人: Joseph Pesek
• 金额: $ 12.62万
• 依托单位: San Jose State University Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-01-01 至 1992-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8814849&HistoricalAwards=false
• 关键词: Synthesis; Novel; Chemically; Bonded; Stationary

This Research in Undergraduate Institution (RUI) project is in the general area of analytical and surface chemistry and in the subfield of separations science. The focus of this research is on the development of new chemically bonded stationary phases for chromatography. In general, the research involves new synthetic approaches to bonding organic moieties to silica as well as modification of alumina surfaces. Four major synthetic steps are proposed involving 1) chlorination/Grignard chemistry, 2) silica hydride intermediates, 3) bonded olefin modification and 4) bonded liquid crystal stationary phases. The ultimate goal of the proposed research is to provide a better understanding of bonded phase interactions and to better understand the role of the support surface in chromatographic separations. This research is designed to better understand how molecules are separated using chromatography. New types of schemes are proposed for preparing novel columns for separating chemicals. The ultimate goal of this research is to provide a better theory for these separations which will in turn allow prediction of better separation schemes.

这个本科生研究机构(RUI)项目是在分析和表面化学的一般领域，在分离科学的子领域。本研究的重点是开发新的化学键合色谱固定相。总体而言，这项研究涉及到将有机部分键合到二氧化硅以及氧化铝表面改性的新的合成方法。提出了四个主要的合成步骤：1)氯化/格氏化学，2)硅氢化物中间体，3)键合烯烃改性和4)键合液晶固定相。拟议研究的最终目标是更好地了解键合相的相互作用，并更好地了解支撑表面在色谱分离中的作用。这项研究旨在更好地了解分子是如何使用层析分离的。提出了制备新型化学分离柱的新方案。这项研究的最终目的是为这些分离提供更好的理论，从而预测更好的分离方案。