Asymmetric Catalysis with Chiral Lewis Bases

本计画探讨借由手性刘易斯碱的引入，各种路易斯酸催化的反应被促进及呈现催化性及/或不对称性的潜力。 该方案涵盖的反应类型是广泛的，直接目标包括不对称醛羟醛缩合反应和醛烯丙基化反应。 支持方法学研究的机制研究包括依赖于超临界流体色谱和快速注射NMR的动力学研究。有了这个奖项，有机和高分子化学计划继续支持Scott E.伊利诺伊大学香槟分校的丹麦。 丹麦教授对反应的合成和机械方面进行基础研究，旨在制备同时控制几个不对称中心的立体化学的小分子。 此外，化学博士生在现代有机化学的概念和行为方面获得了宝贵的知识。

This project explores the potential of various Lewis-acid catalyzed reactions to be promoted and rendered catalytic and/or asymmetric by the introduction of chiral Lewis bases. The types of reactions that this scheme encompasses is extensive, with immediate objectives including asymmetric aldehyde aldol reactions and aldehyde allylation reactions. Mechanistic investigations supporting the methodological studies include kinetic studies relying upon supercritical fluid chromatography and rapid-injection NMR.With this Award, the Organic and Macromolecular Chemistry Program continues its support of the research and educational activities of Professor Scott E. Denmark of the University of Illinois Urbana-Champaign. Professor Denmark conducts fundamental research into synthetic and mechanistic aspects of reactions designed to prepare small molecules controlling the stereochemistry of several centers of asymmetry in a simultaneous fashion. In addition, doctoral students of chemistry gain invaluable knowledge in the conception and conduct of modern organic chemistry.