Asymmetric Nucleophilic Catalysis with Chiral Lewis Bases

手性路易斯碱的不对称亲核催化

• 批准号: 0414440
• 负责人: Scott Denmark
• 金额: $ 61.65万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0414440&HistoricalAwards=false
• 关键词: Asymmetric; Nucleophilic; Catalysis; Chiral; Lewis

The foci of this research involve the invention of catalytic, enantioselective reactions of enoxysilane nucleophiles under catalysis by chiral Lewis base-activated Lewis acids, and the structural and mechanistic investigation of the reactions catalyzed by chiral Lewis bases. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Scott E. Denmark in the Department of Chemistry at the University of Illinois at Urbana-Champaign. Professor Denmark will focus his research on the crossed aldol reaction of aldehydes, one of the most challenging of the carbonyl addition reactions and the chiral Lewis base activation of germanium tetrachloride will also be pursued in this context. The project presents an excellent setting for the training of graduate students and postdoctoral workers. Further, the research has the potential for broader impact in the pharmaceutical industry.

本论文的研究重点是手性刘易斯碱活化的刘易斯酸催化烯氧基硅烷亲核试剂对映体选择性反应的发明以及手性刘易斯碱催化反应的结构和机理研究。有了这个奖项，有机和高分子化学计划是支持博士斯科特E。丹麦，伊利诺伊大学香槟分校化学系。丹麦教授将集中研究醛的交叉羟醛反应，这是最具挑战性的羰基加成反应之一，四氯化锗的手性刘易斯碱活化也将在这方面进行。该项目为培养研究生和博士后工作者提供了一个很好的环境。 此外，这项研究有可能在制药行业产生更广泛的影响。