Asymmetric Nucleophilic Catalysis with Chiral Lewis Bases

本研究的重点是在手性路易斯碱活化的路易斯酸的催化下，发明亲核试剂烯氧基硅烷的对映选择性催化反应，以及手性路易斯碱催化反应的结构和机理研究。通过这个奖项，有机和大分子化学项目支持伊利诺伊大学厄巴纳-香槟分校化学系Scott E. Denmark博士的研究。丹麦教授将重点研究醛的交叉醛醇反应，这是羰基加成反应中最具挑战性的反应之一，四氯化锗的手性路易斯碱活化也将在此背景下进行。该项目为培养研究生和博士后提供了良好的环境。此外，这项研究有可能对制药行业产生更广泛的影响。

The foci of this research involve the invention of catalytic, enantioselective reactions of enoxysilane nucleophiles under catalysis by chiral Lewis base-activated Lewis acids, and the structural and mechanistic investigation of the reactions catalyzed by chiral Lewis bases. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Scott E. Denmark in the Department of Chemistry at the University of Illinois at Urbana-Champaign. Professor Denmark will focus his research on the crossed aldol reaction of aldehydes, one of the most challenging of the carbonyl addition reactions and the chiral Lewis base activation of germanium tetrachloride will also be pursued in this context. The project presents an excellent setting for the training of graduate students and postdoctoral workers. Further, the research has the potential for broader impact in the pharmaceutical industry.