Asymmetric Nucleophilic Catalysis with Chiral Lewis Bases

本研究的重点是在手性Lewis碱活化的Lewis酸催化下烯氧基硅烷亲核试剂的催化、对映选择性反应的发明，以及手性Lewis碱催化反应的结构和机理的研究。通过这一奖项，有机和高分子化学项目支持斯科特·E·丹麦博士在伊利诺伊大学厄巴纳-香槟分校化学系的研究。丹麦教授将重点研究醛的交叉Aldol反应，这是最具挑战性的羰基加成反应之一，四氯化锗的手性Lewis碱活化也将在此背景下进行。该项目为研究生和博士后工作者的培训提供了一个很好的环境。此外，这项研究有可能在制药行业产生更广泛的影响。

The foci of this research involve the invention of catalytic, enantioselective reactions of enoxysilane nucleophiles under catalysis by chiral Lewis base-activated Lewis acids, and the structural and mechanistic investigation of the reactions catalyzed by chiral Lewis bases. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Scott E. Denmark in the Department of Chemistry at the University of Illinois at Urbana-Champaign. Professor Denmark will focus his research on the crossed aldol reaction of aldehydes, one of the most challenging of the carbonyl addition reactions and the chiral Lewis base activation of germanium tetrachloride will also be pursued in this context. The project presents an excellent setting for the training of graduate students and postdoctoral workers. Further, the research has the potential for broader impact in the pharmaceutical industry.