The MYB gene as a model for global transcriptional regulation: stopping, starting and looping

MYB 基因作为全局转录调控的模型：停止、启动和循环

• 批准号: DP0985025
• 负责人: Prof Thomas Gonda
• 金额: $ 24.96万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2013-11-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0985025
• 关键词: MYB; gene; model; global; transcriptional

This project will study how transcriptional elongation controls the MYB gene, a key regulator of normal and cancerous growth and regulation. There are three major benefits that are likely to flow from the proposed research It will strengthen research in new and important areas of transcriptional regulation, by building research capacity in Australia in the area of gene expression, particularly with respect to transcriptional elongation and long-range regulation. It will highlight a new approach to the therapeutic targeting of MYB in cancer: data generated from this research may enable us to target MYB expression in a range of cancers including breast cancer by inhibiting transcriptional elongation. And it will provide training in advanced molecular biology to postdoctoral scientists and students.

该项目将研究转录延伸如何控制MYB基因，MYB基因是正常和癌症生长和调节的关键调节因子。拟议的研究可能带来三大好处：通过在澳大利亚建立基因表达领域的研究能力，特别是在转录延伸和远程调控方面，将加强转录调控新的重要领域的研究。它将突出MYB在癌症中的治疗靶向的新方法：从这项研究中产生的数据可能使我们能够通过抑制转录延伸来靶向MYB在包括乳腺癌在内的一系列癌症中的表达。 它将为博士后科学家和学生提供先进分子生物学的培训。