A comprehensive analysis of Myb target genes involved in myelopoiesis and myeloid transformation

Myb参与骨髓生成和髓样转化的靶基因全面分析

• 批准号: nhmrc : 569639
• 负责人: Prof Thomas Gonda
• 金额: $ 34.09万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/comprehensive-analysis-myb-myeloid-transformation/82859
• 关键词: comprehensive; analysis; Myb; target; genes

The MYB gene is essential for both normal blood cell formation and the growth of leukaemia cells. It acts by switching other genes (target genes) on and off. This project aims to advance our understanding of how MYB functions, by carrying out a comprehensive search for MYB target genes. In particular it will focus on target genes that help explain MYB's ability to control cellular growth and maturation. Some of these target genes may provide leads for future anti-cancer drug development.

MYB基因对正常血细胞形成和白血病细胞生长都是必不可少的。它通过打开和关闭其他基因（靶基因）来发挥作用。该项目旨在通过对MYB靶基因的全面搜索，促进我们对MYB功能的理解。特别是，它将集中在有助于解释MYB控制细胞生长和成熟的能力的靶基因上。其中一些靶基因可能为未来的抗癌药物开发提供线索。