A comprehensive analysis of Myb target genes involved in myelopoiesis and myeloid transformation

MYB基因对于正常的血细胞形成和白血病细胞的生长都是必不可少的。它通过开启和关闭其他基因(靶基因)来发挥作用。这个项目旨在通过对MYB靶基因的全面搜索，促进我们对MYB功能的理解。特别是，它将专注于有助于解释MYB控制细胞生长和成熟的能力的目标基因。其中一些靶基因可能会为未来的抗癌药物开发提供线索。

The MYB gene is essential for both normal blood cell formation and the growth of leukaemia cells. It acts by switching other genes (target genes) on and off. This project aims to advance our understanding of how MYB functions, by carrying out a comprehensive search for MYB target genes. In particular it will focus on target genes that help explain MYB's ability to control cellular growth and maturation. Some of these target genes may provide leads for future anti-cancer drug development.