Adaptive and Survival Strategies of Microorganisms in Biofilms

一个合作研究项目将研究微生物在生物膜中的适应和生存策略。合作小组包括布法罗大学和瑞典马尔默大学的研究人员。该计划有三个目标：作为对诱导假说的明确测试，利用一个研究良好的系统，鉴定变形链球菌H7在耐酸反应早期阶段诱导的一般性和酸特异性应激蛋白，并启动对其功能的研究；建立变形链球菌耐酸性和饥饿反应之间的关系，作为它们作为生物膜附着的底物表面能的函数；以及扩大应激蛋白诱导的研究，包括变形链球菌对动态剪切力的反应，这些剪切力是相关微生物生物膜环境的特征。

A collaborative research program will study adaptive and survival strategies of microorganisms in biofilms. The collaborating team includes researchers at the University of Buffalo and at Malmo University (Sweden). The program has three objectives: as a clear test of the induction hypothesis with a well-studied system, to identify the general and acid-specific stress proteins induced in S. mutans H7 during the early stages of the acid tolerance response and to initiate studies on their function; to establish the relationships between the acid tolerance and starvation responses in S. mutans, as functions of the surface energies of the substrata to which they have attached as biofilms; and to expand the study of the induction of stress proteins to include the response of S. mutnas to dynamic shear stresses that characterize relevant microbial biofilm environments.