Adaptive and Survival Strategies of Microorganisms in Biofilms

生物膜中微生物的适应性和生存策略

• 批准号: 0126460
• 负责人: Robert Baier
• 金额: $ 18万
• 依托单位: SUNY at Buffalo
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0126460&HistoricalAwards=false
• 关键词: Adaptive; Survival; Strategies; Microorganisms; Biofilms

A collaborative research program will study adaptive and survival strategies of microorganisms in biofilms. The collaborating team includes researchers at the University of Buffalo and at Malmo University (Sweden). The program has three objectives: as a clear test of the induction hypothesis with a well-studied system, to identify the general and acid-specific stress proteins induced in S. mutans H7 during the early stages of the acid tolerance response and to initiate studies on their function; to establish the relationships between the acid tolerance and starvation responses in S. mutans, as functions of the surface energies of the substrata to which they have attached as biofilms; and to expand the study of the induction of stress proteins to include the response of S. mutnas to dynamic shear stresses that characterize relevant microbial biofilm environments.

一项合作研究计划将研究生物膜中微生物的适应和生存策略。 合作团队包括布法罗大学和马尔默大学（瑞典）的研究人员。 该计划有三个目标：通过充分研究的系统对诱导假设进行明确的测试，识别在耐酸反应早期阶段在变形链球菌 H7 中诱导的一般和酸特异性应激蛋白，并启动对其功能的研究；建立变形链球菌的耐酸性和饥饿反应之间的关系，作为它们作为生物膜附着的基质的表面能的函数；并扩大应激蛋白诱导的研究，包括 S. mutnas 对表征相关微生物生物膜环境的动态剪切应力的响应。