I-Corps: New Product for "Dry Mouth" Relief

研究人员开发了一种组织对组织的测试，可以发现显著增强润滑剂对“口干”患者的缓解作用，并计划进一步改进润滑剂以缓解“口干”。 通过选择组织对组织摩擦试验，对接触的活组织相互作用的科学理解得到了提高，产生的结果与采用合成材料对立面的所有先前生物润滑性试验显著不同。人类受试者试验，在培养细胞的大量体外试验之后，已经验证了这些预测用于眼科用途，并且现在显示出扩展到缓解老年人，药物影响和辐射癌症患者的“口干”症状的实质性希望。社会已经开始依赖于许多治疗和修复干预措施来延长和改善他们的生活质量和从事生产性工作的能力。老年人难以吞咽必要的药物，这些药物（以及必要的癌症治疗）会产生“口干”的副作用。睡眠中断是由于唾液流量长时间减少导致的组织干燥。通过I-CORPS计划开发的拟议配方有可能为通常浸泡在夜间不存在的唾液中的组织提供8倍的润滑缓解。

Researchers have developed a tissue-on-tissue test that allowed discovery of significantly enhanced lubricant-based relief for "dry mouth" sufferers and plan to further improve a lubricant for the relief of "dry mouth". Improved scientific understanding of the interactions of living tissues in contact has emerged from choice of a tissue-on-tissue frictional test, producing results that significantly differ from all prior tests of bio-lubricity that employed synthetic material counter-faces. Human subject trials, following numerous in vitro tests with cells in culture, have validated these predictions for ophthalmology uses, and substantial promise is now shown for extension to relief of "dry mouth" symptoms of elderly, medicine-influenced, and irradiated cancer sufferers. Society has come to depend upon numerous therapeutic and prosthetic interventions to extend and improve their quality of life and their ability to engage in productive work. Older citizens have difficulty swallowing their necessary medicines, and negative side effects of "dry mouth" from these medicines (as well as from necessary cancer treatments). Interrupted sleep results from tissue desiccation during these long periods of salivary flow reduction. The proposed formula to be developed through this I-CORPS program has the potential to provide 8-times the lubricious relief to tissues normally bathed in overnight-absent saliva.