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I-Corps: New Product for "Dry Mouth" Relief

I-Corps：缓解“口干”的新产品

基本信息

批准号：
1342909
负责人：
Robert Baier
金额：
$ 5万
依托单位：
SUNY at Buffalo
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-01 至 2015-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1342909&HistoricalAwards=false
关键词：
Corps New Product Dry Mouth

项目摘要

Researchers have developed a tissue-on-tissue test that allowed discovery of significantly enhanced lubricant-based relief for "dry mouth" sufferers and plan to further improve a lubricant for the relief of "dry mouth". Improved scientific understanding of the interactions of living tissues in contact has emerged from choice of a tissue-on-tissue frictional test, producing results that significantly differ from all prior tests of bio-lubricity that employed synthetic material counter-faces. Human subject trials, following numerous in vitro tests with cells in culture, have validated these predictions for ophthalmology uses, and substantial promise is now shown for extension to relief of "dry mouth" symptoms of elderly, medicine-influenced, and irradiated cancer sufferers. Society has come to depend upon numerous therapeutic and prosthetic interventions to extend and improve their quality of life and their ability to engage in productive work. Older citizens have difficulty swallowing their necessary medicines, and negative side effects of "dry mouth" from these medicines (as well as from necessary cancer treatments). Interrupted sleep results from tissue desiccation during these long periods of salivary flow reduction. The proposed formula to be developed through this I-CORPS program has the potential to provide 8-times the lubricious relief to tissues normally bathed in overnight-absent saliva.

研究人员开发了一种组织对组织的测试，发现了显著增强的基于润滑剂的缓解“口干”患者的效果，并计划进一步改进缓解“口干”的润滑剂。通过选择组织对组织的摩擦测试，提高了对接触中的活组织相互作用的科学理解，产生的结果与之前使用合成材料对抗面进行的所有生物润滑测试明显不同。在对培养细胞进行了大量体外试验之后，人体试验验证了这些预测在眼科的应用，并且现在显示出了大量的希望，可以扩展到缓解老年人、受药物影响和受辐射的癌症患者的“口干”症状。社会已经开始依赖于许多治疗和假肢干预来延长和改善他们的生活质量和从事生产性工作的能力。老年人有吞咽必要药物的困难，以及这些药物（以及必要的癌症治疗）的“口干”的负面副作用。睡眠中断是由于长时间的唾液流量减少造成的组织干燥。通过I-CORPS计划开发的拟议配方有可能为通常浸泡在隔夜缺失唾液中的组织提供8倍的颜色缓解。