I-Corps: New Product for "Dry Mouth" Relief

研究人员已经开发出一种组织对组织的测试，可以发现显著增强的润滑剂对“口干”患者的缓解作用，并计划进一步改进一种用于缓解“口干”的润滑剂。由于选择了组织对组织摩擦测试，提高了对接触中活组织相互作用的科学理解，产生的结果与之前使用合成材料对接表面进行的所有生物润滑性测试显著不同。在对培养的细胞进行了大量的体外试验后，人体受试者试验已经证实了这些预测在眼科应用中的应用，现在显示出很有希望扩大到缓解老年、受药物影响的和受辐射的癌症患者的“口干”症状。社会已经开始依赖许多治疗和假肢干预来延长和提高他们的生活质量和从事生产性工作的能力。老年人吞咽必要的药物有困难，这些药物(以及必要的癌症治疗)产生的“口干”副作用。睡眠中断是由于在唾液流量减少的这些长时间内组织干燥造成的。通过I-Corps计划开发的拟议配方有可能为通常沐浴在夜间无唾液中的组织提供8倍的色泽缓解。

Researchers have developed a tissue-on-tissue test that allowed discovery of significantly enhanced lubricant-based relief for "dry mouth" sufferers and plan to further improve a lubricant for the relief of "dry mouth". Improved scientific understanding of the interactions of living tissues in contact has emerged from choice of a tissue-on-tissue frictional test, producing results that significantly differ from all prior tests of bio-lubricity that employed synthetic material counter-faces. Human subject trials, following numerous in vitro tests with cells in culture, have validated these predictions for ophthalmology uses, and substantial promise is now shown for extension to relief of "dry mouth" symptoms of elderly, medicine-influenced, and irradiated cancer sufferers. Society has come to depend upon numerous therapeutic and prosthetic interventions to extend and improve their quality of life and their ability to engage in productive work. Older citizens have difficulty swallowing their necessary medicines, and negative side effects of "dry mouth" from these medicines (as well as from necessary cancer treatments). Interrupted sleep results from tissue desiccation during these long periods of salivary flow reduction. The proposed formula to be developed through this I-CORPS program has the potential to provide 8-times the lubricious relief to tissues normally bathed in overnight-absent saliva.