Industry/University Cooperative Research Center for Biosurfaces

这项为期五年的持续奖励使迈阿密大学加入了多所大学的生物表面工业/大学合作研究中心。该中心现在由纽约州立大学布法罗分校（领头）、孟菲斯州立大学、阿尔弗雷德大学和迈阿密大学组成。中心继续发展协作和协同。孟菲斯州立大学低于行业资金要求，因此，如果不满足项目要求，未来的资金将减少。以下是拟建新中心的长期目标：(1)表征在不同有机/无机含量的水介质中促进或生物粘附的各种合成基质的表面化学/物理性质，包括与肺、眼睛、口腔、皮肤或体内环境接触的材料。(2)确定生物流体和细胞与特征良好的基质相互作用时的表面特性，特别关注介质流动的动力学、细胞到达、表面修饰、生物附着和附着机制的最终稳定性，例如在伤口愈合中观察到的。(3)记录细胞与相邻细胞、膜与周围介质之间的反应，以及其他交叉反应，特别关注在实际环境、职业或治疗情况下可能控制这些相互作用以促进或防止生物粘附的技术。(4)将这些生物技术扩大到宏观系统过程，如过滤和净化，利用安全有效的结构材料和配方来改善健康和舒适。提供额外资金，以支持多大学中心的额外行政活动。美国陆军正在提供资金，以扩大正在进行的研究计划，并获得该中心的会员资格。通过妇女、少数民族和残疾人工程研究助理项目为一名女本科生提供资助。该学生将与迈阿密大学研究中心主任黄禹锡博士一起参与一个中心项目，该项目与百特诺雅高心脏辅助装置测试和评估所需的文件系统设计有关。

ABSTRACT EEC-9712629 BAIER This five year continuing award adds the University of Miami to the multi-university Industry/University Cooperative Research Center for Biosurfaces. The Center will now be composed of the State University of New York at Buffalo (lead), Memphis State University, Alfred University, and the University of Miami. The center continues to develop collaboration and synergy. Memphis State University is below the industry funding requirements, therefore future funding will be reduced if the program requirements are not met. These are the Long Term Goals and Objectives of the proposed new Center: (1) Characterization of the surface chemical/physical properties of various synthetic substrata that promote or bioadhesion, in aqueous media of varied organic/inorganic content, including materials contacting the lungs, eyes, mouth, skin, or interior body environments. (2) Determination of the surface properties of biofluids and cells as they engage in interactions with well-characterized substrata, giving special attention to the dynamics of media flow, cell arrival, surface modification, bio-attachment and -finally-stability of the attachment mechanisms, as observed in wound healing, for instance. (3) Documentation of reactions between cells and adjacent cells, films and surrounding media, and other cross-reactions, with particular attention to technology that may control these interactions to either promote or prevent bioadhesion in practical environment, occupational or therapeutic situations. (4) Scale-up of these biotechnologies to macrosystem processes, like filtration and purification, that utilize safe and effective structural materials and formulations for improved health and comfort. Additional funds to provide support for the extra administrative activities of a multi-university Center are provided. The U.S. Department of Army is providing funding to augment the ongoing research program and to obtain a membership in the Center. Funding for a woman undergraduate research student is being providing through the Women, Minorities, and Disabled Engineering Research Assistants Program. The student will work with Dr. Hwang, the director of the University of Miami research site, on a center project related to the design of documentation systems needed for the testing and evaluation of the Baxter Novacor cardiac assist devices.