Industry/University Cooperative Research Center for Biosurfaces

生物表面产学合作研究中心

• 批准号: 9416826
• 负责人: Robert Baier
• 金额: $ 81万
• 依托单位: SUNY at Buffalo
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-15 至 1998-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9416826&HistoricalAwards=false
• 关键词: Industry; University; Cooperative; Research; Center

9416826 Baier The Industry/University Cooperative Research Center for Biosurfaces is becoming a multi-site university Center. The State University of New York at Buffalo's Industry/University Cooperative Research Center for Biosurfaces is being joined by a research site at the University of Memphis and another research site at the New York State College of Ceramics. Research in the multi-site Center will address: 1) Characterization of the chemical/physical properties of various substrata that favor or inhibit bioadhesion, in aqueous media of varied organic/inorganic content; 2) Determination of the surface properties of cells as they engage in interactions with well- characterized substrata, giving special attention to the dynamics of media flow, cell arrival, surface modification, bio-attachment and -- finally -- stability of the attachment mechanisms; 3) Documentation of reactions between cells and supporting films, cells and adjacent cells, films and surrounding media, and other cross-reactions, with particular attention to technology that may control these interactions to either promote or prevent bioadhesion in practical biomedical or bioengineering situations; and 4) Scale- up of these biotechnologies to macrosystem processes, like adhesive secretion or biomineralization, that may produce new, or mimic existing, materials such as structural composite shells and adhesives of natural organisms. This multi-site Center has been coordinated with Dr. Norman Caplan, Program Director, Environmental Systems Program. The State University of New York has requested funding to support undergraduate research assistants. These students will participate in the Center's ongoing research projects. Additional funding is provided through a supplemental Research Opportunity Award (ROA) for a woman Assistant Professor at D'Youville College to perform research for the State University of New - Buffalo. Pa ge 1 of 2 The Project is determining the protein structure associated with bioadhesives functionality. The project's goal is to study the protein structures responsible for the binding ability of selected native adhesive protein domains and for their use in the development of manufactured proteinaceous adhesive agents. The Program Manager recommends the State University of New York at Buffalo be awarded: $50,000 for the first year of a five-year continuing award (including $25,000 for administrative activities); $50,000 for the first year of a five-year continuing award to the University of Memphis through a subcontract; $50,000 for the first year of a five-year continuing award to the New York State College of Ceramics through a subcontract; $5,000 for one year with funds provided by the Women, Minorities, and Disabled Engineering Research Assistants Program; and $54,995 for 24 months for a Research Opportunity award. Near the end of each 12-month period the Program Manager and/or the Division Director of the Engineering Education Centers Division will review the progress of the Center on a number of renewal criteria requirements, including the following: 1) the extent to which the industry/university interaction is developing; 2) the extent to which support base is developing; and 3) the extent to which a robust research program is developing. If the review is satisfactory, the Program Manager will recommend support for the next period of this continuing award. Page 2 of 2

小行星9416826 生物表面工业/大学合作研究中心正在成为一个多地点的大学中心。 位于布法罗的纽约州立大学的生物表面工业/大学合作研究中心正在加入孟菲斯大学的一个研究中心和纽约州立陶瓷学院的另一个研究中心。 在多站点中心的研究将解决：1）表征有利于或抑制生物粘附的各种基质的化学/物理性质，在不同的有机/无机含量的水介质中; 2）当细胞与充分表征的基质相互作用时，确定细胞的表面性质，特别注意培养基流动的动力学，细胞到达，表面修饰，3）记录细胞与支持膜、细胞与相邻细胞、膜与周围介质之间的反应以及其它交叉反应，特别关注可控制这些相互作用以在实际生物医学或生物工程情况下促进或防止生物粘附的技术;以及4）将这些生物技术按比例放大到宏观系统过程，如粘附分泌或生物矿化，其可以产生新的或模拟现有的材料，如结构复合壳和天然生物体的粘合剂。 这个多站点中心与环境系统项目主任Norman Caplan博士进行了协调。 纽约的州立大学已经申请资助本科生研究助理。 这些学生将参加该中心正在进行的研究项目。 通过补充研究机会奖（罗阿）为德尤维尔学院的一名女助理教授提供额外资金，为新布法罗的州立大学进行研究。 第1页，共2页 该项目正在确定与生物粘合剂功能相关的蛋白质结构。 该项目的目标是研究负责选定的天然粘附蛋白结构域的结合能力的蛋白质结构，以及它们在制造蛋白质粘附剂的开发中的用途。 项目经理建议授予布法罗的纽约州立大学：五年连续奖励的第一年50，000美元（包括行政活动费25 000美元）;通过一个基金向孟菲斯大学连续提供五年奖学金，第一年50 000美元; 50，000美元的第一年，为期五年的连续奖励，以陶瓷的纽约州立大学通过一个奖学金; 5，000美元的一年由妇女，少数民族和残疾人工程研究助理计划提供的资金; 24个月的研究机会奖为54，995美元。 在每12个月结束时，项目经理和/或工程教育中心部门的部门主任将根据一些更新标准要求审查中心的进展情况，包括以下内容：1）行业/大学互动的发展程度; 2）支持基础的发展程度;以及3）一个强大的研究计划正在发展的程度。 如果评审结果令人满意，计划经理将建议在此持续奖励的下一个期间提供支持。 第2页共2