Purchase of an Electrospray/MALDI Q-TOF Hybrid Mass Spectrometer

购买电喷雾/MALDI Q-TOF 混合质谱仪

• 批准号: 0130752
• 负责人: Michael Sepaniak
• 金额: $ 36.7万
• 依托单位: University of Tennessee Knoxville
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-01 至 2005-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0130752&HistoricalAwards=false
• 关键词: Purchase; Electrospray; MALDI; TOF; Hybrid

With support from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the University of Tennessee in Knoxville will acquire an Electrospray/Matrix-assisted Laser Desorption Ionization Quadrupole - Time of Flight (MALDI Q-TOF) Hybrid Mass Spectrometer. This instrument will be used for a) studies on the characterization of polymers and amyloid fibrils; studies of multiply charged anions; and for the synthesis and characterization of telechelic materials. In addition, investigators at Knoxville will investigate aminoglycoside antibiotic modifying enzymes; light regulation of plant development; and protein components of amyloid plaques. Matrix-assisted laser desorption ionization (MALDI) time-of-flight (TOF) mass spectrometry is the technique of choice for obtaining accurate molecular weights on molecules up to and over 300,000 daltons, with extremely high sensitivity. These studies utilizing the MALDI-TOF mass spectrometer will have an impact in chemistry, biochemistry and materials research.

在化学研究仪器和设施（CRIF）计划的支持下，位于诺克斯维尔的田纳西大学化学系将获得电喷雾/基质辅助激光解吸电离四极杆飞行时间（MALDI Q-TOF）混合质谱仪。 该仪器将用于a）聚合物和淀粉样蛋白原纤维表征的研究;多电荷阴离子的研究;以及遥爪材料的合成和表征。 此外，诺克斯维尔的研究人员将研究氨基糖苷类抗生素修饰酶;植物发育的光调节;和淀粉样蛋白斑块的蛋白质成分。 基质辅助激光解吸电离（MALDI）飞行时间（TOF）质谱是获得高达和超过300，000道尔顿的分子的精确分子量的首选技术，具有极高的灵敏度。 这些利用MALDI-TOF质谱仪的研究将对化学、生物化学和材料研究产生影响。