Purchase of an Electrospray/MALDI Q-TOF Hybrid Mass Spectrometer

在化学研究仪器和设施（CRIF）项目的支持下，位于诺克斯维尔的田纳西大学化学系将获得一台电喷雾/基质辅助激光解吸电离四极杆飞行时间（MALDI Q-TOF）混合质谱仪。该仪器将用于a)聚合物和淀粉样原纤维的表征研究；多电荷阴离子的研究；以及远旋材料的合成和表征。此外，诺克斯维尔的研究人员将研究氨基糖苷类抗生素修饰酶；植物发育的光调控；以及淀粉样斑块的蛋白质成分。矩阵辅助激光解吸电离（MALDI）飞行时间（TOF）质谱法是获得精确分子质量的技术选择高达和超过300,000道尔顿，具有极高的灵敏度。这些利用MALDI-TOF质谱仪的研究将对化学、生物化学和材料研究产生影响。

With support from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the University of Tennessee in Knoxville will acquire an Electrospray/Matrix-assisted Laser Desorption Ionization Quadrupole - Time of Flight (MALDI Q-TOF) Hybrid Mass Spectrometer. This instrument will be used for a) studies on the characterization of polymers and amyloid fibrils; studies of multiply charged anions; and for the synthesis and characterization of telechelic materials. In addition, investigators at Knoxville will investigate aminoglycoside antibiotic modifying enzymes; light regulation of plant development; and protein components of amyloid plaques. Matrix-assisted laser desorption ionization (MALDI) time-of-flight (TOF) mass spectrometry is the technique of choice for obtaining accurate molecular weights on molecules up to and over 300,000 daltons, with extremely high sensitivity. These studies utilizing the MALDI-TOF mass spectrometer will have an impact in chemistry, biochemistry and materials research.