FASEB Conference: Transcriptional Regulation During Cell Growth, Differentiation and Development; June 29 - July 4, 2002, Saxtons River, Vermont

该项目为将于2002年6月29日至7月4日在佛蒙特州萨克顿河举行的由FASEB主持的“细胞生长、分化和发育过程中的转录调控”会议提供部分资金。 通过转录进行基因调控是所有生物系统共有的基本过程。 转录调控是细胞行为的关键方面，包括增殖、对环境信号的响应、分化和多细胞生物体的发育。 本次会议的目的是汇集研究人员从事研究广泛的转录过程在不同的生物系统和使用不同的方法。 会议的目的是沟通的基本机制的转录激活和抑制，染色质结构和基因表达的长期和表观遗传效应的知识，以及这些机制的生物学响应环境信号，发展和细胞周期控制的关系的最新进展。 会议将强调转录调控在正常分化和发育中的重要作用，以及异常基因表达参与癌症和其他疾病的方式。 这次会议不同于其他转录会议，因为它不只是关注分子机制，而是强调细胞如何利用转录来解决发育和分化的特定问题。 因此，会议将包括各种物种遇到和解决的问题，包括酵母，蠕虫，苍蝇和哺乳动物，以便可以理解的相似性和差异。 会议将包括正式会谈，讨论阶段，两个非正式的为期两天的海报会议，以及与会科学家之间互动的绝佳机会。 与会者将包括主要研究人员，博士后研究员和研究生。 33%的受邀发言人和8/9的会议主席是女性，54%的受邀发言人是本次会议的新成员。 会议将提供生物学中最基本和最快速发展的领域之一的最新概述，并有望为未来的研究产生新的方向。

This project provides partial funding for a conference on "Transcriptional Regulation During Cell Growth, Differentiation, and Development" to be held under the auspices of FASEB at Saxtons River, Vermont, from June 29-July 4, 2002. Gene regulation through transcription is a fundamental process common to all biological systems. Transcriptional regulation underlies critical aspects of cell behavior including proliferation, response to environmental signals, differentiation, and the development of multicellular organisms. The intent of this conference is to bring together researchers engaged in studying a broad range of transcriptional processes in different biological systems and using different methodologies. The sessions are designed to communicate recent advances in knowledge of fundamental mechanisms of transcriptional activation and repression, chromatin structure, and long-range and epigenetic effects on gene expression, and the relationship of these mechanisms to the biology of response to environmental signals, development, and cell-cycle control. The conference will underscore the important role that transcriptional regulation plays in normal differentiation and development and the manner in which aberrant gene expression is involved in cancer and other diseases. This conference differs from other transcription meetings in that it does not focus simply on molecular mechanisms but rather emphasizes how transcription is used by cells to solve particular problems of development and differentiation. As such, the meeting will include problems encountered and solved across a wide range of species, including yeast, worms, flies, and mammals, such that the similarities and differences can be appreciated. The meeting will include formal talks, discussion periods, two informal 2-day poster sessions, and excellent opportunities for interaction among the attending scientists. Attendees will include principal investigators, postdoctoral fellows, and graduate students. 33% of the invited speakers and 8/9 session chairs are women, and 54% of the invited speakers are new to this meeting. The conference will provide an up-to-date overview of one of the most fundamental and rapidly moving fields in biology and is expected to generate new directions for future research.