CAREER: Investigating Membrane Proteins wth Magnetic Resonance Spectroscopy

职业：利用磁共振波谱研究膜蛋白

• 批准号: 0133433
• 负责人: Gary Lorigan
• 金额: $ 46.07万
• 依托单位: Miami University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0133433&HistoricalAwards=false
• 关键词: CAREER; Investigating; Membrane; Proteins; wth

Dr. Gary A. Lorigan of Miami University (Oxford, OH) is funded for his research in magnetic resonance studies of membrane proteins by a CAREER grant in the Physical Chemistry program of the Chemistry Division and in the Molecular Biophysics program of the Molecular and Cellular Biosciences Division. He will develop model membrane systems that magnetically align at low magnetic fields for magnetic resonance studies. A Q-band EPR spectrometer will be used to explore the structural and dynamic properties of model membrane systems and integral membrane proteins. Dr. Lorigan will develop a modern biophysical chemistry curriculum for undergraduate and graduate students in both the classroom and the laboratory.Magnetic resonance spectroscopy is an important technique that is rapidly becoming a standard tool in chemistry and biochemistry for the structural determination of proteins. This research will allow biophysical chemists to investigate the structural and motional properties of biologically significant molecules. Dr. Lorigan plans on developing new course work in the area of biophysical chemistry for both undergraduate and graduate students.

迈阿密大学(牛津，俄亥俄州)的加里·A·洛根博士获得了化学部物理化学项目和分子和细胞生物科学部分子生物物理学项目的职业资助，用于膜蛋白的磁共振研究。他将开发在低磁场下磁性对准的膜系统模型，用于磁共振研究。Q波段EPR光谱仪将用于探索模型膜系统和完整膜蛋白的结构和动力学性质。洛根博士将在课堂和实验室中为本科生和研究生开发一门现代生物物理化学课程。磁共振波谱是一项重要的技术，正在迅速成为化学和生物化学中用于确定蛋白质结构的标准工具。这项研究将使生物物理化学家能够研究具有生物意义的分子的结构和运动性质。洛根博士计划为本科生和研究生开发生物物理化学领域的新课程。