RUI: Applications in Capillary Electrophoresis

该奖项授予加州州立大学洛杉矶分校的Frank Gomez教授，由化学学部的分析和表面化学项目提供支持。主要目的是将柱上反应与基于亲和的分离相结合，以实现高通量合成和快速分析的双重目的。此外，毛细管电泳将进一步发展，以评估底物-蛋白质和底物- dna相互作用的结合常数。研究疾病和改善公众健康需要新的分析技术。拟议的研究将侧重于通过检查模型生物系统来开发这些新技术，其长期目标是开发有用的技术来研究包括癌症、阿尔茨海默氏症和帕金森病在内的疾病。此外，通过研究化学和化学相关学科的交叉问题，本研究将为本科生和少数民族学生提供扎实的化学背景知识。为参与者计划的研究项目旨在展示电子计算的跨学科性质，以及它作为解决广泛科学问题的一种令人兴奋的新工具的重要性。

This award to Professor Frank Gomez of the California State University, Los Angeles, is supported by the Analytical and Surface Chemistry Program in the Chemistry Division. A primary objective is to couple on-column reactions with affinity-based separations for the dual purposes of high-throughput synthesis and rapid analysis. In addition, capillary electrophoresis will be further developed to assess binding constants for substrate-protein and substrate-DNA interactions.New analytical techniques are needed for the study of disease and improve public health. The proposed studies will focus on developing these new techniques by examining model biological systems with the long-term goal of developing useful techniques to study diseases including cancer, Alzheimer's, and Parkinsons. In addition, the proposed research effort will provide undergraduate and minority students a solid background in chemistry by examining problems at the interface of chemistry and chemistry-related disciplines. The research projects planned for the participants are aimed at demonstrating the interdisciplinary nature of CE and its importance as a new and exciting instrument in solving broad scientific problems.