Isomerizations of Isotopically Labeled Hydrocarbons

在有机和大分子化学项目的支持下，雪城大学化学系的John E. Baldwin教授正在研究同位素标记碳氢化合物的异构化反应。Baldwin教授正在确定螺戊烷和环丙烷的单中心和双中心异位化的相对重要性，并获得了次生氘动力学同位素对这些立体突变的影响的第一个实验测量。此外，他还在探索其他一些基本的碳氢化合物异构化，包括环丙烷通过1-丙烯转化为丙烯，[1,3]-碳转移，[1,5]-氢转移，通过中间的双环[4.1.1]-2,4-二烯的双环[5.1.0]辛-2,4-二烯的相互转化，以及“碳-克拉森”重排。烃类小分子的热反应在基本的有机反应化学和烃重整等大型石油化工过程中都起着关键作用。雪城大学化学系的约翰·e·鲍德温教授正在研究各种小分子的热转化。通过结合稳定同位素，鲍德温教授能够获得这些转变的全面视图，获得对反应机制的见解，这将最终导致对简单有机化学品的热反应特征如何发生的基本理解。

With the support of the Organic and Macromolecular Chemistry Program, Professor John E. Baldwin, of the Department of Chemistry at Syracuse University, is studying isomerization reactions of isotopically labeled hydrocarbons. Professor Baldwin is establishing the relative importance of one-center and two-center epimerizations in spiropentanes and cyclopropanes and obtaining the first experimental measures of secondary deuterium kinetic isotope effects on these stereomutations. In addition, he is exploring a number of other fundamental hydrocarbon isomerizations, including the conversion of cyclopropane to propylene via 1-propylidene, [1,3]-carbon shifts, [1,5]-hydrogen shifts, interconversion of bicyclo[5.1.0]octa-2,4-dienes via intermediate bicyclo[4.1.1]octa-2,4-dienes, and "carbo-Claisen" rearrangements.Thermal reactions of small hydrocarbon molecules play key roles both in fundamental organic reaction chemistry and in large-scale petrochemical processes such as hydrocarbon reforming. Professor John E. Baldwin, of the Department of Chemistry at Syracuse University, is studying the thermal transformations of a variety of small molecules. By incorporating stable isotopes, Professor Baldwin is able to obtain a comprehensive view of these transformations, obtaining insights into the reaction mechanisms which will ultimately lead to a fundamental understanding of how thermal reactions characteristic of simple organic chemicals occur.