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Isomerizations of Isotopically Labeled Hydrocarbons

同位素标记的烃的异构化

基本信息

批准号：
0514376
负责人：
John Baldwin
金额：
$ 44.73万
依托单位：
Syracuse University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2005
资助国家：
美国
起止时间：
2005-08-01 至 2009-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0514376&HistoricalAwards=false
关键词：
Isomerizations Isotopically Labeled Hydrocarbons

项目摘要

With this award, the Organic and Macromolecular Chemistry Program continues its support of the work of Professor John Baldwin, of the Chemistry Department at Syracuse University. The research will extend the PI's studies of fundamental reaction mechanisms occurring in the rearrangement of hydrocarbons. These investigations, utilizing sophisticated experimental techniques, offer particularly attractive opportunities to test modern theoretical predictions. The hydrocarbon rearrangements to be studied include the isomerization of cyclopropane to propylene, the reaction path leading from the pentamethylene diradical to propylene, conversion of vinylcyclobutanes into isomeric cyclohexenes, and isomerizations of 1,3-cycloalkadienes. The methods and techniques that will be employed in these experiments include organic synthesis, the use of stable isotopes, application of many different spectroscopic tools, and kinetic and stereochemical analyses.These investigations of the mechanisms of hydrocarbon thermal rearrangements, which will provide fundamental new information on chemical reactivity, are expected to have significant impact on much of synthetic chemistry. A major positive benefit of this research will be the young scientists nurtured by participation in the project. These undergraduates, graduate students, and post-doctoral fellows will become part of the human capital so essential for new scientific advances.

凭借这一奖项，有机化学和高分子化学项目继续支持锡拉丘兹大学化学系约翰·鲍德温教授的工作。这项研究将扩展PI对烃类重排中发生的基本反应机理的研究。这些研究利用复杂的实验技术，提供了特别有吸引力的机会来检验现代理论预测。需要研究的烃类重排包括环丙烷异构化为丙烯，从五亚甲基二基到丙烯的反应路径，乙烯基环丁烷转化为异构体环己烯，以及1，3-环二烯的异构化。这些实验将采用的方法和技术包括有机合成，稳定同位素的使用，许多不同光谱工具的应用，以及动力学和立体化学分析。这些对碳氢化合物热重排机理的研究将提供关于化学反应活性的基本新信息，预计将对合成化学的许多方面产生重大影响。这项研究的一个主要积极好处将是通过参与该项目培养的年轻科学家。这些本科生、研究生和博士后研究员将成为人力资本的一部分，对新的科学进步至关重要。