Isomerizations of Isotopically Labeled Hydrocarbons

有了这个奖项，有机和大分子化学项目继续支持雪城大学化学系约翰·鲍德温教授的工作。这项研究将扩展PI对碳氢化合物重排中发生的基本反应机制的研究。这些研究利用了复杂的实验技术，为检验现代理论预测提供了特别有吸引力的机会。所研究的烃类重排包括环丙烷到丙烯的异构化、五亚甲基二自由基到丙烯的反应路径、乙烯基环丁烷到异构环己烯的转化以及1,3-环烷二烯的异构化。这些实验将采用的方法和技术包括有机合成、稳定同位素的使用、许多不同光谱工具的应用以及动力学和立体化学分析。这些对碳氢化合物热重排机理的研究将为化学反应性提供基本的新信息，预计将对合成化学的许多方面产生重大影响。这项研究的一个主要积极好处将是参与该项目的年轻科学家得到培养。这些本科生、研究生和博士后研究员将成为人力资本的一部分，对新的科学进步至关重要。

With this award, the Organic and Macromolecular Chemistry Program continues its support of the work of Professor John Baldwin, of the Chemistry Department at Syracuse University. The research will extend the PI's studies of fundamental reaction mechanisms occurring in the rearrangement of hydrocarbons. These investigations, utilizing sophisticated experimental techniques, offer particularly attractive opportunities to test modern theoretical predictions. The hydrocarbon rearrangements to be studied include the isomerization of cyclopropane to propylene, the reaction path leading from the pentamethylene diradical to propylene, conversion of vinylcyclobutanes into isomeric cyclohexenes, and isomerizations of 1,3-cycloalkadienes. The methods and techniques that will be employed in these experiments include organic synthesis, the use of stable isotopes, application of many different spectroscopic tools, and kinetic and stereochemical analyses.These investigations of the mechanisms of hydrocarbon thermal rearrangements, which will provide fundamental new information on chemical reactivity, are expected to have significant impact on much of synthetic chemistry. A major positive benefit of this research will be the young scientists nurtured by participation in the project. These undergraduates, graduate students, and post-doctoral fellows will become part of the human capital so essential for new scientific advances.