Isomerizations of Isotopically Labeled Hydrocarbons

有了这个奖项，有机和高分子化学计划继续支持锡拉丘兹大学化学系的约翰·鲍德温教授的工作。 该研究将扩展PI对碳氢化合物重排中发生的基本反应机理的研究。 这些调查，利用先进的实验技术，提供了特别有吸引力的机会来测试现代理论预测。 研究的烃重排包括环丙烷异构化为丙烯、五亚甲基双自由基转化为丙烯的反应路径、乙烯基环丁烷转化为异构的环己烯以及1，3-环二烯的异构化。 这些实验将采用的方法和技术包括有机合成、稳定同位素的使用、多种光谱工具的应用以及动力学和立体化学分析。这些对碳氢化合物热重排机理的研究将提供有关化学反应性的基本新信息，预计将对许多合成化学产生重大影响。 这项研究的一个主要积极效益将是通过参与该项目培养年轻科学家。这些本科生、研究生和博士后研究员将成为新的科学进步所必需的人力资本的一部分。

With this award, the Organic and Macromolecular Chemistry Program continues its support of the work of Professor John Baldwin, of the Chemistry Department at Syracuse University. The research will extend the PI's studies of fundamental reaction mechanisms occurring in the rearrangement of hydrocarbons. These investigations, utilizing sophisticated experimental techniques, offer particularly attractive opportunities to test modern theoretical predictions. The hydrocarbon rearrangements to be studied include the isomerization of cyclopropane to propylene, the reaction path leading from the pentamethylene diradical to propylene, conversion of vinylcyclobutanes into isomeric cyclohexenes, and isomerizations of 1,3-cycloalkadienes. The methods and techniques that will be employed in these experiments include organic synthesis, the use of stable isotopes, application of many different spectroscopic tools, and kinetic and stereochemical analyses.These investigations of the mechanisms of hydrocarbon thermal rearrangements, which will provide fundamental new information on chemical reactivity, are expected to have significant impact on much of synthetic chemistry. A major positive benefit of this research will be the young scientists nurtured by participation in the project. These undergraduates, graduate students, and post-doctoral fellows will become part of the human capital so essential for new scientific advances.