GOALI: Fixation of CO2 for Use in Radiopharmaceuticals

GOALI：固定二氧化碳用于放射性药物

• 批准号: 0213165
• 负责人: Richard Kemp
• 金额: $ 42万
• 依托单位: University of New Mexico
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0213165&HistoricalAwards=false
• 关键词: GOALI; Fixation; CO2; Use; Radiopharmaceuticals

Dr. Richard Kemp, Department of Chemistry, University of New Mexico, is supported by the Inorganic, Bioinorganic, and Organometallic Chemistry Program of the Chemistry Division for research into the rapid fixation of carbon dioxide into organic molecules. There is a need for C-11 containing compounds for several applications, including positron emission tomography (PET). Due to the short half-life of C-11 rapid incorporation of C-11 carbon dioxide is required if these species are to be obtained. The objective of this research is to develop routes to incorporate C-11 carbon dioxide into organic products in less than one hour. Carbon dioxide is known to slowly insert into subvalent group 14 amides to produce isocyanate and/or carbodiimide. Building on the observation that changes in ligand structure and main group metal can dramatically affect CO2 incorporation rates, low-valent Ge, Sn, and Pb reagents will be prepared with a variety of ligands. Their reaction with carbon dioxide will be studied in order to determine the factors that influence the reaction rate. Group 14 compounds will then be developed into catalysts by using various silylated organic amines as substrates. Finally, related compounds not based on Group 14 bis(amides), which should also react with CO2 to produce isocyanates, will be studied. In this project, methods will be developed to rapidly incorporate radioactive C-11 into organic molecules. These species are required for several applications including PET. This is a GOALI project that involves collaborative efforts between the University of New Mexico and General Electric Corp. The research includes developing the basic science behind rapid carbon dioxide incorporation. The eventual goal is new industrial preparations of valuable radioactive products. Both graduate and postdoctoral students will gain experience in multitask interdisciplinary objectives as part of a collaboration with industry. It is likely that students from traditionally under-represented groups will participate in this research.

新墨西哥州大学化学系的Richard肯普博士得到化学系无机、生物无机和有机化学项目的支持，研究将二氧化碳快速固定为有机分子。 需要含C-11的化合物用于多种应用，包括正电子发射断层扫描（PET）。由于C-11的半衰期短，如果要获得这些物质，则需要快速掺入C-11二氧化碳。这项研究的目的是开发在不到一小时的时间内将C-11二氧化碳掺入有机产品的路线。已知二氧化碳缓慢插入低价第14族酰胺中以产生异氰酸酯和/或碳二亚胺。基于配体结构和主族金属的变化可以显著影响CO2掺入率的观察，将用各种配体制备低价Ge、Sn和Pb试剂。将研究它们与二氧化碳的反应，以确定影响反应速率的因素。第14族化合物然后将通过使用各种甲硅烷基化的有机胺作为底物开发成催化剂。最后，将研究不基于第14族双（酰胺）的相关化合物，其也应该与CO2反应以产生异氰酸酯。在该项目中，将开发将放射性C-11快速掺入有机分子的方法。包括PET在内的多种应用都需要这些物质。这是一个GOALI项目，涉及新墨西哥州大学和通用电气公司之间的合作努力，研究包括发展背后的快速二氧化碳纳入基础科学。最终的目标是有价值的放射性产品的新的工业制备。研究生和博士后学生将获得多任务跨学科目标的经验，作为与行业合作的一部分。传统上代表性不足的群体的学生很可能会参加这项研究。