GOALI: Fixation of CO2 for Use in Radiopharmaceuticals

新墨西哥大学化学系Richard Kemp博士得到化学部无机、生物无机和有机金属化学项目的支持，研究二氧化碳快速固定成有机分子的过程。需要含有C-11的化合物用于几种应用，包括正电子发射断层扫描(PET)。由于C-11的半衰期很短，如果要获得这些物种，需要快速并入C-11二氧化碳。这项研究的目标是开发在不到一小时的时间内将C-11二氧化碳合并到有机产品中的方法。已知二氧化碳缓慢地插入亚价族14酰胺中以产生异氰酸酯和/或碳二亚胺。在观察到配体结构和主族金属的变化会显著影响二氧化碳的掺入速率的基础上，将用各种配体制备低价Ge、锡和铅试剂。将研究它们与二氧化碳的反应，以确定影响反应速度的因素。然后，通过使用各种硅烷化有机胺作为底物，第14族化合物将被开发成催化剂。最后，将研究不是基于第14族双(酰胺)的相关化合物，这些化合物也应该与二氧化碳反应生成异氰酸酯。在这个项目中，将开发将放射性C-11快速结合到有机分子中的方法。这些物种是包括PET在内的几种应用所必需的。这是一个目标项目，涉及新墨西哥大学和通用电气公司的合作努力。这项研究包括发展快速二氧化碳吸收背后的基础科学。最终目标是有价值的放射性产品的新工业制剂。作为与行业合作的一部分，研究生和博士后都将在多任务跨学科目标方面获得经验。来自传统上代表性不足的群体的学生很可能会参与这项研究。

Dr. Richard Kemp, Department of Chemistry, University of New Mexico, is supported by the Inorganic, Bioinorganic, and Organometallic Chemistry Program of the Chemistry Division for research into the rapid fixation of carbon dioxide into organic molecules. There is a need for C-11 containing compounds for several applications, including positron emission tomography (PET). Due to the short half-life of C-11 rapid incorporation of C-11 carbon dioxide is required if these species are to be obtained. The objective of this research is to develop routes to incorporate C-11 carbon dioxide into organic products in less than one hour. Carbon dioxide is known to slowly insert into subvalent group 14 amides to produce isocyanate and/or carbodiimide. Building on the observation that changes in ligand structure and main group metal can dramatically affect CO2 incorporation rates, low-valent Ge, Sn, and Pb reagents will be prepared with a variety of ligands. Their reaction with carbon dioxide will be studied in order to determine the factors that influence the reaction rate. Group 14 compounds will then be developed into catalysts by using various silylated organic amines as substrates. Finally, related compounds not based on Group 14 bis(amides), which should also react with CO2 to produce isocyanates, will be studied. In this project, methods will be developed to rapidly incorporate radioactive C-11 into organic molecules. These species are required for several applications including PET. This is a GOALI project that involves collaborative efforts between the University of New Mexico and General Electric Corp. The research includes developing the basic science behind rapid carbon dioxide incorporation. The eventual goal is new industrial preparations of valuable radioactive products. Both graduate and postdoctoral students will gain experience in multitask interdisciplinary objectives as part of a collaboration with industry. It is likely that students from traditionally under-represented groups will participate in this research.