Acquisition of a 400 MHz NMR Spectrometer for Use in Research, Teaching, and Research Training at Earlham College

有了这个主要研究仪器(MRI)项目的奖励，厄勒姆学院化学系将获得一台400 MHz的核磁共振光谱仪。该设备将使研究人员能够开展以下研究：a)在Mitsunobu和改进的Mitsunobu条件下一系列环β-羟基叔胺的扩环和收缩的合成应用；b)植物铁载体类似物的合成，这是一种可促进分子主动转移到禾本科植物根部的天然化合物；c)氧化损伤对蛋白质的影响；d)NAD前体对糖尿病大鼠心脏高能磷酸代谢和糖酵解的影响。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对许多领域产生影响，特别是分子生物学。

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Earlham College will acquire a 400 MHz NMR Spectrometer. This equipment will enable researchers to carry out studies on a) the synthetic applications of ring expansions and contractions of a series of cyclic beta-hydroxy tertiary amines under Mitsunobu and modified Mitsunobu conditions; b) the synthesis of phytosiderophores analogues, natural compounds that may facilitate active transfer of molecules into the roots of grasses; c) the effects of oxidative damage on proteins; and d) the effects of an NAD+ precursor on high energy phosphate metabolism and glycolysis in hearts from diabetic rats. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas, in particular molecular biology .