MRI: Acquisition of a 400 MHz NMR Spectrometer for Research and Education
MRI:采购 400 MHz NMR 波谱仪用于研究和教育
基本信息
- 批准号:2117776
- 负责人:
- 金额:$ 34.17万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-01 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Northern Illinois University is acquiring a 400 MHz nuclear magnetic resonance (NMR) spectrometer to support research of Professor Evgueni Nesterov and colleagues Narayan Hosmane, Ralph Wheeler, Douglas Klumpp and Timothy Hagen. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as permitting study of chemically and biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument is an integral part of teaching as well as research and research training of undergraduate and graduate students in chemistry and biochemistry at this institution as well as collaborators from regional primarily undergraduate institutions.The award of the NMR spectrometer is aimed at enhancing research and education at all levels. It especially impacts studies developing synthetic organic methodology and transition metal and super-acid catalyzed reactions. The instrumentation is also used for fundamental studies in organic photochemistry and the design and study of small-molecule ligands for protein binding. In addition, it allows the development of an analytical platform for fluorescent screening of enzyme inhibitors and studies on the methods of controlled preparation of semiconducting polymer materials and advanced dual-function organic light-emitting diode (OLED) compounds. The instrument also serves researchers developing environmentally friendly industrially relevant catalytic processes and reactions and those designing oligonucleotide-based molecular switches. The NMR spectrometer is employed in the characterization of synthesized boron-carbon cage compounds which are used in neutron-capture therapy.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
该奖项由主要研究仪器和化学研究仪器计划支持。北方伊利诺伊大学正在购买一台400 MHz核磁共振(NMR)光谱仪,以支持Evgueni Nesterov教授及其同事Narayan Hosmane、Ralph惠勒、道格拉斯克伦普和蒂莫西哈根的研究。该光谱仪可用于各种领域的研究,例如加速具有重要经济意义的化学反应,以及允许研究化学和生物学相关物种。一般来说,核磁共振(NMR)光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质,表征分子内原子的特定排列,并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说,使用最先进的NMR光谱仪是必不可少的。该仪器是该机构化学和生物化学本科生和研究生的教学、研究和研究培训的一个组成部分,也是区域主要本科院校合作者的一个组成部分。授予NMR光谱仪的目的是加强各级的研究和教育。它特别影响了有机合成方法学和过渡金属及超强酸催化反应的研究。该仪器还用于有机光化学的基础研究以及蛋白质结合的小分子配体的设计和研究。此外,它还允许开发用于酶抑制剂荧光筛选的分析平台,并研究半导体聚合物材料和先进双功能有机发光二极管(OLED)化合物的可控制备方法。 该仪器还为开发环境友好的工业相关催化过程和反应的研究人员以及设计基于磷脂的分子开关的研究人员提供服务。NMR光谱仪用于表征用于中子捕获治疗的合成硼碳笼化合物。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Electrophilic heterocycles: Functionalization with enol silyl ethers
- DOI:10.1016/j.tet.2023.133511
- 发表时间:2023-08
- 期刊:
- 影响因子:2.1
- 作者:Grant P. Holmin;Jacob C. Hood;Hong Xue;D. Klumpp
- 通讯作者:Grant P. Holmin;Jacob C. Hood;Hong Xue;D. Klumpp
Bacterial structural genomics target enabled by a recently discovered potent fungal acetyl-CoA synthetase inhibitor
最近发现的有效真菌乙酰辅酶A合成酶抑制剂实现了细菌结构基因组学目标
- DOI:10.1107/s2053230x23003801
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:DeBouver, Nicholas D.;Bolejack, Madison J.;Esan, Taiwo E.;Krysan, Damian J.;Hagen, Timothy J.;Abendroth, Jan
- 通讯作者:Abendroth, Jan
Zero-Background Small-Molecule Sensors for Near-IR Fluorescent Imaging of Biomacromolecular Targets in Cells
- DOI:10.1021/acssensors.2c02342
- 发表时间:2023-03-03
- 期刊:
- 影响因子:8.9
- 作者:Mohamed,Myar;Klenke,Anastasia K.;Nesterova,Irina V.
- 通讯作者:Nesterova,Irina V.
Condensations with biaryl ethers and carbonyl groups leading to spirocycles
与联芳基醚和羰基缩合形成螺环
- DOI:10.1016/j.tet.2022.133123
- 发表时间:2022
- 期刊:
- 影响因子:2.1
- 作者:Ferreira, Jeffrey C.;Hood, Jacob C.;Klumpp, Douglas A.
- 通讯作者:Klumpp, Douglas A.
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Evgueni Nesterov其他文献
Evgueni Nesterov的其他文献
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{{ truncateString('Evgueni Nesterov', 18)}}的其他基金
Mechanistic and Exploratory Photochemistry with Plane-Polarized Light
平面偏振光的机理和探索性光化学
- 批准号:
2155026 - 财政年份:2022
- 资助金额:
$ 34.17万 - 项目类别:
Continuing Grant
Development of Controlled Polymerization for Hierarchically Organized Conjugated Polymers
多级共轭聚合物的受控聚合研究进展
- 批准号:
2004117 - 财政年份:2020
- 资助金额:
$ 34.17万 - 项目类别:
Standard Grant
EAGER: Controlling Photochemistry via Spatially Selective Excitation
EAGER:通过空间选择性激发控制光化学
- 批准号:
1901671 - 财政年份:2019
- 资助金额:
$ 34.17万 - 项目类别:
Standard Grant
"Higher Energy Gap" Control Principle in Fluorescent Conjugated Polymers
荧光共轭聚合物的“高能隙”控制原理
- 批准号:
1362686 - 财政年份:2014
- 资助金额:
$ 34.17万 - 项目类别:
Standard Grant
"Bottom-Up" Design of Nanostructured Conducting Polymer Thin Films
纳米结构导电聚合物薄膜的“自下而上”设计
- 批准号:
1006336 - 财政年份:2010
- 资助金额:
$ 34.17万 - 项目类别:
Continuing Grant
CAREER: Conjugated Systems Displaying Tunable Energy Transfer: Fundamental Principles and Applications
职业:显示可调谐能量传输的共轭系统:基本原理和应用
- 批准号:
0547895 - 财政年份:2006
- 资助金额:
$ 34.17万 - 项目类别:
Standard Grant
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