MRI: Acquisition of 400 MHz NMR Spectrometer for Chemistry Research

MRI：购买 400 MHz NMR 波谱仪用于化学研究

• 批准号: 2216273
• 负责人: Thomas Mobley
• 金额: $ 40万
• 依托单位: Grinnell College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2216273&HistoricalAwards=false
• 关键词: MRI; Acquisition; 400; MHz; NMR

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs, and the Established Program to Stimulate Competitive Research. Grinnell College is acquiring an upgraded console for a 400 MHz nuclear magnetic resonance (NMR) spectrometer with a diffusion probe to support the research of Professor Andrew Mobley and colleagues Erick Leggans, Leslie Lyons, Molly MacInnes, and Stephen Sieck. This instrument facilitates research in the areas of organic chemistry, organometallic chemistry, natural products, and material science. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument enhances the educational, research, and teaching efforts of students at all levels in many departments at Grinnell College as well as provides accessibility for use at nearby institutions. The instrument also enables the research groups to work actively to recruit students from a diverse background and broaden the representation of minoritized groups in the sciences.The award of the NMR spectrometer is aimed at enhancing the research and education at all levels, especially in areas such as organic chemistry, organometallic chemistry, natural products, and material science. The instrument impacts research focused on advancing the understanding of heterobimetallic complexes and ion transport in electrolytes and graphitic networks. Specifically, the instrument will be used in a wide spectrum of projects such as: 1) heteronuclear NOE and NMR-relaxation studies of Sn hydride complexes of W and Pt, 2) detailed variable temperature structural studies of the conformational behavior of the natural product lugdunin, 3) structural determination of the interaction between solvent and metal ions in electrolytes for Li-ion and Na batteries, 4) self-diffusion studies of Li, Na, and Ln ions in graphitic suspensions, and 5) J-coupling studies to determine the configuration and solution state conformation of novel chalcones. The research projects to be enabled by the 400MHz NMR spectrometer could lead to impacts in the fields such as energy storage and biotechnology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器计划以及刺激竞争性研究的既定计划共同支持。 格林内尔学院正在为400 MHz核磁共振（NMR）光谱仪购买一个升级的控制台，该光谱仪带有扩散探针，以支持Andrew Mobley教授及其同事Erick Leggans，Leslie里昂，Molly MacInnes和Stephen Sieck的研究。 该仪器促进了有机化学、有机金属化学、天然产物和材料科学领域的研究。 一般来说，核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。该工具提高了教育，研究和学生在格林内尔学院的许多部门的各级教学工作，以及提供在附近的机构使用的可访问性。 该仪器还使研究小组能够积极开展工作，招募来自不同背景的学生，扩大少数群体在科学领域的代表性。授予NMR光谱仪旨在加强各级研究和教育，特别是在有机化学，有机金属化学，天然产物和材料科学等领域。该仪器影响的研究重点是促进对电解质和石墨网络中的杂环化合物和离子传输的理解。具体而言，该工具将用于广泛的项目，例如：1）W和Pt的Sn氢化物络合物的杂原子NOE和NMR弛豫研究，2）天然产物lugdunin的构象行为的详细变温结构研究，3）Li离子和Na电池电解质中溶剂和金属离子之间相互作用的结构测定，4）Li、Na和Ln离子在石墨悬浮液中的自扩散研究，以及5）J-耦合研究，以确定新型查耳酮的构型和溶液状态构象。400 MHz核磁共振波谱仪支持的研究项目可能会在能源储存和生物技术等领域产生影响。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。