MRI: Development of a Colloidal Force-Distance-Adsorption Apparatus for Particle Science Research and Education

MRI：开发用于粒子科学研究和教育的胶体力距离吸附装置

• 批准号: 0216129
• 负责人: Joseph Merola
• 金额: $ 39.5万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-15 至 2006-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0216129&HistoricalAwards=false
• 关键词: MRI; Development; Colloidal; Force; Distance

With this award from the Major Research Instrumentation program Virginia Polytechnic Institute and State University will develop a new experimental tool for measuring colloidal forces. An understanding of these forces is important in materials science, cell biology, soil science, waste disposal and water purification, ceramic engineering, the development of personal products, and in quality control in the microelectronics industry. The instrument will combine capabilities of atomic force microscopy (AFM) and total internal reflection microscopy (TIRM), while overcoming most of the drawbacks for each technique. The instrument will provide a new capability: the ability to measure adsorption isotherms during particle collisions. The atomic force microscope is currently the most widely used method for measuring colloidal forces. A major problem with this application is that the separation between the particle and the surface is not measured; it is derived indirectly. With this apparatus, the separation will be obtained directly, from the scattering intensity from an evanescent wave produced by totally reflecting a laser beam at the substrate/fluid interface. This approach is based on the TIRM technique. The TIRM technique will be improved through modulation of the scattered evanescent wave. The adsorption of material to surfaces is the main method by which colloidal forces can be modulated, so it is useful to determine adsorption during particle interactions. We will develop a technique for measuring adsorption during collisions using fluorescent tags on the adsorbates. Graduate and undergraduate students will participate in this instrument development project.Many of the objects that we encounter in everyday life actually consist of very fine particles. For example, bricks, paper, clothing, china, soil, most foods, cosmetics, and even humans are composed of small particles. The physical properties (e.g. stiffness, flow, and workability) of these objects depends on the forces between the particles. Part of the process of creating new and improved products is the manipulation of the forces between particles to obtain desirable material properties. The first stage of manipulating these forces is to measure them. With this award from the Major Research Instrumentation program Virginia Polytechnic Institute and State University will develop a new experimental tool for measuring the forces acting on particles. The new apparatus will combine existing techniques, the force probe from Atomic Force Microscopy and the distance probe from Total Internal Reflectance Microscopy, and incorporate improvements through the use of signal modulation and fluorescent tagging of molecules. A graduate student and undergraduate students will participate in this instrument development project.

有了这项来自主要研究仪器计划的奖项，弗吉尼亚理工学院和州立大学将开发一种新的测量胶体力的实验工具。 对这些力的理解在材料科学、细胞生物学、土壤科学、废物处理和水净化、陶瓷工程、个人产品的开发以及微电子工业的质量控制中是重要的。 该仪器将结合联合收割机的原子力显微镜（AFM）和全内反射显微镜（TIRM）的能力，同时克服每种技术的大多数缺点。 该仪器将提供一种新的能力：在粒子碰撞过程中测量吸附等温线的能力。 原子力显微镜是目前应用最广泛的胶体力测量方法。 这种应用的一个主要问题是，颗粒和表面之间的分离没有测量;它是间接得出的。 利用该装置，将直接从由在基底/流体界面处全反射激光束产生的倏逝波的散射强度获得分离。 该方法基于TIRM技术。通过对散射倏逝波的调制，可以改善TIRM技术。材料在表面的吸附是调节胶体力的主要方法，因此在颗粒相互作用期间确定吸附是有用的。 我们将开发一种技术，用于测量吸附碰撞过程中使用荧光标记的吸附物。研究生和本科生将参与这个仪器开发项目。我们在日常生活中遇到的许多物体实际上都是由非常细的颗粒组成的。 例如，砖、纸、衣服、瓷器、土壤、大多数食物、化妆品，甚至人类都是由小颗粒组成的。 这些物体的物理性质（例如硬度、流动性和可加工性）取决于颗粒之间的力。 创造新的和改进的产品的过程的一部分是操纵粒子之间的力，以获得所需的材料特性。 操纵这些力的第一步是测量它们。有了这项来自主要研究仪器计划的奖项，弗吉尼亚理工学院和州立大学将开发一种新的实验工具来测量作用在粒子上的力。 新设备将结合联合收割机现有的技术，力探针从原子力显微镜和距离探针从全内反射显微镜，并纳入改进通过使用信号调制和荧光标记的分子。一名研究生和一名本科生将参与该仪器开发项目。