QSB: Development of an Integrated Biological and Computational Approach to Decipher Transcriptional Regulatory Networks in Saccharromyces Cerevisiae

QSB：开发一种综合生物学和计算方法来破译酿酒酵母的转录调控网络

• 批准号: 0223056
• 负责人: Leroy Hood
• 金额: --
• 依托单位: Institute for Systems Biology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0223056&HistoricalAwards=false
• 关键词: QSB; Development; Integrated; Biological; Computational

The long range goal of this project is to develop an integrated biological and computational approach to decipher gene regulatory networks. This project combines discovery-based approaches to identify and characterize new regulatory networks with hypothesis-driven approaches in which transcriptional control by two regulatory factors important in galactose metabolism will be examined. The specific aims of this project are: (1) to temporally profile the global genetic and proteomic response to galactose; (2) to globally identify the elements of transcriptional networks important for galactose utilization; (3) to develop an advanced computational framework for integration, modeling, and prediction of transcriptional networks; and (4) to experimentally test the networks models predicted from these studies.

该项目的长期目标是开发一种综合的生物学和计算方法来破译基因调控网络。 该项目结合发现为基础的方法，以确定和表征新的监管网络与假设驱动的方法，其中转录控制的两个重要的半乳糖代谢调控因子将被检查。 该项目的具体目标是：（1）在时间上分析全球遗传和蛋白质组对半乳糖的反应;（2）在全球范围内识别对半乳糖利用重要的转录网络的元素;（3）开发一个先进的计算框架，用于整合，建模和预测转录网络;（4）实验测试这些研究预测的网络模型。