QSB: Development of an Integrated Biological and Computational Approach to Decipher Transcriptional Regulatory Networks in Saccharromyces Cerevisiae

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The long range goal of this project is to develop an integrated biological and computational approach to decipher gene regulatory networks. This project combines discovery-based approaches to identify and characterize new regulatory networks with hypothesis-driven approaches in which transcriptional control by two regulatory factors important in galactose metabolism will be examined. The specific aims of this project are: (1) to temporally profile the global genetic and proteomic response to galactose; (2) to globally identify the elements of transcriptional networks important for galactose utilization; (3) to develop an advanced computational framework for integration, modeling, and prediction of transcriptional networks; and (4) to experimentally test the networks models predicted from these studies.