fMRI Analysis of Emotion Regulation and its Developmental Trajectory

情绪调节及其发展轨迹的fMRI分析

• 批准号: 0224342
• 负责人: John Gabrieli
• 金额: $ 77.61万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0224342&HistoricalAwards=false
• 关键词: fMRI; Analysis; Emotion; Regulation; its

FMRI Analysis of Emotion Regulation and Its Developmental TrajectoryAbstractWith National Science Foundation support, Dr. Gabrieli and colleagues will conduct a three-year investigation of the maturation of the brain systems that support emotion regulation using functional magnetic resonance imaging (fMRI), a noninvasive technique that can identify brain regions recruited for specific emotion and cognition processes. Children and young adults, ages 8 to 30, will participate in two experiments that examine how they regulate an initial emotional response to either highly negative or highly positive photos. These studies will identify what brain regions initially respond to negative or positive emotional experiences, and what brain regions then support cognitive regulation of those emotional responses. Of greatest interest is how these brain responses mature, or change, from late childhood through early adulthood.Emotion regulation, the subject of this research, is a fundamental aspect of human experience and behavior, and the interaction between thoughts (cognition) and feelings (emotions) that guides how people evaluate and act on what is going on around them. Successful emotion regulation makes people resilient to difficult circumstances, and thus can help people avoid distress or psychiatric diseases such as major depression. Successful regulation also promotes prosocial behaviors, such as not behaving violently in response to feelings of anger. It is generally thought that children and adolescents have emotions as strongly felt as do adults, but that the cognitive regulation of emotion matures slowly as children and adolescents learn how to regulate their feelings in ways that promote positive social interaction and long-term mental health. Risky behaviors that pose severe health threats for adolescents may reflect the faster maturation of emotion than cognitive aspects of emotion regulation. Although emotion regulation is thus important for health and for social functioning, little is known about its underlying cognitive and neural mechanisms. For example, it is unknown whether people use the same brain systems to regulate negative and positive emotions. Further, nothing is known about how these mechanisms support the normal maturation of emotion regulation in childhood and adolescents. The findings from this research may also illuminate the roots of mental diseases that reflect a disadvantageous development of emotion regulation pathways of the human brain.

情绪调节及其发展轨迹的 FMRI 分析摘要在国家科学基金会的支持下，Gabrieli 博士及其同事将使用功能性磁共振成像 (fMRI) 对支持情绪调节的大脑系统的成熟度进行为期三年的研究，fMRI 是一种非侵入性技术，可以识别为特定情绪和认知过程而招募的大脑区域。 8 至 30 岁的儿童和年轻人将参加两项实验，研究他们如何调节对高度负面或高度正面照片的最初情绪反应。 这些研究将确定哪些大脑区域最初对消极或积极的情绪体验做出反应，以及哪些大脑区域支持这些情绪反应的认知调节。 最令人感兴趣的是这些大脑反应如何从童年晚期到成年早期成熟或变化。本研究的主题是情绪调节，它是人类经验和行为的一个基本方面，也是指导人们如何评估周围发生的事情并采取行动的思想（认知）和感觉（情绪）之间的相互作用。 成功的情绪调节使人们能够适应困难的情况，从而可以帮助人们避免痛苦或精神疾病，例如重度抑郁症。 成功的监管还可以促进亲社会行为，例如不要因愤怒而采取暴力行为。 人们普遍认为，儿童和青少年与成年人一样有强烈的情绪感受，但随着儿童和青少年学会如何以促进积极的社会互动和长期心理健康的方式调节自己的情绪，情绪的认知调节就会慢慢成熟。 对青少年构成严重健康威胁的危险行为可能反映出情绪比情绪调节的认知方面更快成熟。 因此，尽管情绪调节对于健康和社会功能很重要，但对其潜在的认知和神经机制知之甚少。例如，人们是否使用相同的大脑系统来调节消极和积极情绪尚不清楚。 此外，我们对这些机制如何支持儿童和青少年情绪调节的正常成熟一无所知。 这项研究的结果还可能阐明精神疾病的根源，这些疾病反映了人类大脑情绪调节途径的不利发展。