Fate and Transport of an Endocrine Disruptor in Soil-Water Systems

土壤-水系统中内分泌干扰物的归宿和运输

基本信息

  • 批准号:
    0244169
  • 负责人:
  • 金额:
    $ 34.97万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2003
  • 资助国家:
    美国
  • 起止时间:
    2003-05-01 至 2007-04-30
  • 项目状态:
    已结题

项目摘要

0244169 Casey The objectives of our proposed project are to identify the fate and transport mechanisms of the endocrine disrupting chemical (EDC), 17b-estradiol, in soil-water systems. We chose 17b-estradiol because it is a prototype for many EDCs, it has high potency, it has the potential of being prevalent in the environment, and little is known about it. Our purpose for doing this research extends beyond academic interests. We hope to share the results from this research to advance the knowledge of exposure to EDCs in the environment; to increase our ability to predict the mobility and persistence of EDCs in the environment; to use the result to help develop methods to treat polluted soil and water or to remediate contaminated areas; and to educate and train the local community to promote awareness and interest in this research.In the environment, EDCs interfere with endocrine systems by disrupting normal function and/or interfering with development at all life stages. Often, EDCs mimic the reproductive hormones (e.g., estrogens) produced naturally by humans and wildlife, and can produce adverse effects at remarkably low concentrations ( 1 ng L -1 ). Numerous studies have suggested that EDCs have caused widespread physiological and reproductive disorders in birds, fish, shellfish, turtles, gastropods, and mammals. Additionally, EDCs have been implicated in recent adverse trends in human reproduction (i.e., an increase in female breast cancer and decrease in male sperm counts). A recent reconnaissance of surface waters in the U.S. has detected EDCs in approximately 50% of the 139 streams tested. However, little or nothing is known about the fate of these chemicals and how they move in soil before they contaminate our groundwater andsurface water resources.To achieve the objectives of this research, we formed a unique research team that includeindividuals from biochemistry, soil science, mathematical modeling, and biosystems engineering and environmental sciences. We developed six goals: 1) identify fate and transport mechanisms of 17b-estradiol and metabolites in soil; 2) identify transformation/degradation mechanisms of 17b-estradiol to form metabolites; 3) discover the influence of preferential flow on the transport of estrogens; 4) develop, apply, and evaluate a predictive computer model; 5) integrate this research with education; and 6) disseminate this research to a broader community using presentations and publications. We proposed experimental methods and strategies that would be used to accomplish each of these goals. A series of soil batch, degradation, and column experiments would be used to identify the sorption, transformations, and mobility of 17b-estradiol and its metabolites in a variety of soils with different particle sizes, organic matter contents, and structures. This information would be used to formulate a hypothesis of fate and transport and develop a computer model, which would be used to analyze the data. The research would be integrated into education by recruiting graduate students, by including this research in university courses, and by developing a close working relationship with a local K-12 teacher. Preliminary research done by the team of collaborators on this proposal demonstrates the likelihood of success of this project. Furthermore, the proposed project improves networks and partnerships of individuals from diverse areas and backgrounds. The networking of different organizations will also improve facilities by making unique analytical equipment available to other institutions that do not have access to these instruments.
我们提出的项目的目标是确定内分泌干扰化学物质(EDC), 17b-雌二醇,在土壤-水系统中的命运和运输机制。我们选择17b-雌二醇是因为它是许多edc的原型,它有很高的效力,它有可能在环境中普遍存在,而我们对它知之甚少。我们做这项研究的目的超出了学术兴趣。我们希望分享这项研究的结果,以促进对环境中EDCs暴露的认识;提高我们预测环境中EDCs的流动性和持久性的能力;利用研究结果帮助制定处理受污染土壤和水或修复受污染地区的方法;并教育和培训当地社区,以提高对这项研究的认识和兴趣。在环境中,EDCs通过破坏正常功能和/或干扰生命各个阶段的发育来干扰内分泌系统。通常,EDCs模拟人类和野生动物自然产生的生殖激素(例如雌激素),并且在非常低的浓度(1 ng L -1)下可产生不利影响。大量研究表明,EDCs在鸟类、鱼类、贝类、海龟、腹足类和哺乳动物中引起了广泛的生理和生殖障碍。此外,EDCs与最近人类生殖的不利趋势(即女性乳腺癌的增加和男性精子数量的减少)有关。最近对美国地表水的一项调查发现,在139条被检测的河流中,约有50%的河流中检测到EDCs。然而,人们对这些化学物质的命运知之甚少,也不知道它们在污染地下水和地表水资源之前是如何在土壤中移动的。为了实现这项研究的目标,我们组建了一个独特的研究团队,其中包括来自生物化学,土壤科学,数学建模,生物系统工程和环境科学的个人。我们的研究目标有六个:1)确定17b-雌二醇及其代谢物在土壤中的归宿和转运机制;2)确定17b-雌二醇转化/降解形成代谢物的机制;3)发现优先流对雌激素转运的影响;4)开发、应用和评估预测计算机模型;5)将本研究与教育相结合;6)通过演讲和出版物将这项研究传播到更广泛的社区。我们提出了将用于实现这些目标的实验方法和策略。通过一系列的土壤批次、降解和柱状实验来鉴定17b-雌二醇及其代谢物在不同粒径、有机质含量和结构的土壤中的吸附、转化和迁移。这些资料将用于制订一个关于命运和运输的假设,并开发一个计算机模型,用于分析这些数据。这项研究将通过招收研究生、将这项研究纳入大学课程、与当地K-12教师建立密切的工作关系等方式融入教育。合作者团队对这一建议所做的初步研究表明,这一项目成功的可能性。此外,拟议的项目改善了来自不同地区和背景的个人的网络和伙伴关系。不同组织的联网也将改善设施,使其他没有机会使用这些仪器的机构能够获得独特的分析设备。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Francis Casey其他文献

1891 Simulation free MR-guided prostate radiotherapy: using diagnostic MR for reference planning
1891模拟无磁共振引导的前列腺放射治疗:使用诊断性磁共振进行参考计划
  • DOI:
    10.1016/s0167-8140(25)00716-9
  • 发表时间:
    2025-05-01
  • 期刊:
  • 影响因子:
    5.300
  • 作者:
    Francis Casey;Joan Chick;Norina Predescu;Szabolcs-Botond Lőrincz-Molnár;Sian Cooper;Sophie Alexander;Simeon Nill;Uwe Oelfke;Alison Tree;Alex Dunlop
  • 通讯作者:
    Alex Dunlop
2289: Initial Evaluation of Radiographer Target Volume Online Contouring for Bladder MRIgRT
2289:射线照相仪的初步评估在线膀胱构造MRIGRT
  • DOI:
    10.1016/s0167-8140(24)02517-9
  • 发表时间:
    2024-05-01
  • 期刊:
  • 影响因子:
    5.300
  • 作者:
    Bethany Williams;Jonathan Mohajer;Sophie Alexander;Helen Barnes;Shabanaz Boodhoo;Francis Casey;Joan Chick;Alex Dunlop;Trina Herbert;Robert Huddart;Manasi Ingle;Jayde Nartey;Simeon Nill;Priyanka Patel;Gillian Smith;Hubert Stankiewicz;Shaista Hafeez;Helen McNair
  • 通讯作者:
    Helen McNair
Perfluorooctanoic Acid Transport in Soil and Absorption and Distribution in Alfalfa (<em>Medicago sativa</em>)
  • DOI:
    10.4315/jfp-21-276
  • 发表时间:
    2022-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Sara J. Lupton;Francis Casey;David J. Smith;Heldur Hakk
  • 通讯作者:
    Heldur Hakk
QUALITY OF LIFE FOR CHILDREN WITH COMPLEX CONGENITAL HEART DISEASE
患有复杂先天性心脏病儿童的生活质量
  • DOI:
    10.1203/00006450-199211000-00089
  • 发表时间:
    1992-11-01
  • 期刊:
  • 影响因子:
    3.100
  • 作者:
    Francis Casey;Connor Mulholland;Brian Craig
  • 通讯作者:
    Brian Craig

Francis Casey的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Francis Casey', 18)}}的其他基金

Effects of Animal Manure Storage and Disposal on the Fate and Transport of Manure-Borne Hormones
动物粪便储存和处置对粪便激素的去向和运输的影响
  • 批准号:
    0730492
  • 财政年份:
    2007
  • 资助金额:
    $ 34.97万
  • 项目类别:
    Standard Grant

相似国自然基金

Toward a general theory of intermittent aeolian and fluvial nonsuspended sediment transport
  • 批准号:
  • 批准年份:
    2022
  • 资助金额:
    55 万元
  • 项目类别:
Intraflagellar Transport运输纤毛蛋白的分子机理
  • 批准号:
    31371354
  • 批准年份:
    2013
  • 资助金额:
    90.0 万元
  • 项目类别:
    面上项目
苜蓿根瘤菌(S.meliloti)四碳二羧酸转运系统 (Dicarboxylate transport system, Dct系统)跨膜信号转导机理
  • 批准号:
    30870030
  • 批准年份:
    2008
  • 资助金额:
    30.0 万元
  • 项目类别:
    面上项目

相似海外基金

Mechanisms regulating transendothelial transport of endocrine hormones and their significance
内分泌激素跨内皮转运的调节机制及其意义
  • 批准号:
    RGPIN-2017-05713
  • 财政年份:
    2022
  • 资助金额:
    $ 34.97万
  • 项目类别:
    Discovery Grants Program - Individual
Mechanisms regulating transendothelial transport of endocrine hormones and their significance
内分泌激素跨内皮转运的调节机制及其意义
  • 批准号:
    RGPIN-2017-05713
  • 财政年份:
    2021
  • 资助金额:
    $ 34.97万
  • 项目类别:
    Discovery Grants Program - Individual
Mechanisms regulating transendothelial transport of endocrine hormones and their significance
内分泌激素跨内皮转运的调节机制及其意义
  • 批准号:
    RGPIN-2017-05713
  • 财政年份:
    2020
  • 资助金额:
    $ 34.97万
  • 项目类别:
    Discovery Grants Program - Individual
Mechanisms regulating transendothelial transport of endocrine hormones and their significance
内分泌激素跨内皮转运的调节机制及其意义
  • 批准号:
    RGPIN-2017-05713
  • 财政年份:
    2019
  • 资助金额:
    $ 34.97万
  • 项目类别:
    Discovery Grants Program - Individual
Mechanisms regulating transendothelial transport of endocrine hormones and their significance
内分泌激素跨内皮转运的调节机制及其意义
  • 批准号:
    RGPIN-2017-05713
  • 财政年份:
    2018
  • 资助金额:
    $ 34.97万
  • 项目类别:
    Discovery Grants Program - Individual
Mechanisms regulating transendothelial transport of endocrine hormones and their significance
内分泌激素跨内皮转运的调节机制及其意义
  • 批准号:
    RGPIN-2017-05713
  • 财政年份:
    2017
  • 资助金额:
    $ 34.97万
  • 项目类别:
    Discovery Grants Program - Individual
Transport of Endocrine Disruptors in Phospholipid Bilayer Membranes
磷脂双层膜中内分泌干扰物的转运
  • 批准号:
    14540531
  • 财政年份:
    2002
  • 资助金额:
    $ 34.97万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
ENDOCRINE CONTROL OF RBC AND ADIPOSE SUGAR TRANSPORT
红细胞和脂肪糖运输的内分泌控制
  • 批准号:
    3154432
  • 财政年份:
    1985
  • 资助金额:
    $ 34.97万
  • 项目类别:
Probing the Molecular Basis of Endocrine Control of Erythrocyte Hexose Transport Symmetry and its Relationship to Adipocyte Hexose Transfer
探讨内分泌控制红细胞己糖转运对称性的分子基础及其与脂肪细胞己糖转运的关系
  • 批准号:
    8510876
  • 财政年份:
    1985
  • 资助金额:
    $ 34.97万
  • 项目类别:
    Continuing Grant
METABOLIC AND ENDOCRINE CONTROL OF SUGAR TRANSPORT
糖运输的代谢和内分泌控制
  • 批准号:
    3234404
  • 财政年份:
    1985
  • 资助金额:
    $ 34.97万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了