NIRT: Robust Manufacturing Protocol for Particulate-like Nanoporous Micro-devices (NMDs) for Biomedical and Biochemical Applications (Manufacturing Processes at the Nanoscale)

NIRT：用于生物医学和生化应用的颗粒状纳米多孔微器件 (NMD) 的稳健制造协议（纳米级制造工艺）

• 批准号: 0304112
• 负责人: Ly James Lee
• 金额: --
• 依托单位: Ohio State University Research Foundation -DO NOT USE
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-15 至 2008-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0304112&HistoricalAwards=false
• 关键词: NIRT; Robust; Manufacturing; Protocol; Particulate

This project proposes to develop a robust and versatile manufacturing protocol based on the selective integration of distinct micro- and nano-scale fabrication modules. These modules include polymer micro-imprinting and nano-imprinting (the 'top down' approach), and surface self-assembly of nanoporous silica and biomolecular attachment (the 'bottom up' approach) for the mass-production of polymer or polymer/silica nanoporous micro-devices (NMDs) that have particulate-like structures with well-defined non-spherical 3D geometry, nano-scale diffusion pore/channels, and molecular targeting function. In comparison with conventional spherical micro- and nano-particles, these particulate-like NMDs will provide larger and multi-face surface area for increased functionality, well-defined particle shape for better control of flow dynamics, and highly specific targeting and release capability. Fundamental studies on critical issues such as the science of processing biodegradable and biocompatible polymers at micro- and nano-scale; modeling of polymer micro-/nano-imprinting; and nanofluidics of controlled drug release through nanopores/channels will also be addressed.The research will be conducted by an interdisciplinary team that includes five researchers from biomedical engineering, chemical engineering, and mechanical engineering departments with expertise on micro-/nano-fabrication, nano-scale machining and measurements, interfacial phenomena and molecular self-assembly, biomolecules and surfactants, and multi-phase fluidization. Although the research will focus on the fabrication of drug delivery devices, the same methodology can be easily applied to a variety of BioMEMS (biosensors, bioreactors, tissue scaffolds) or other MEMs/NEMS devices.

该项目提出了一个强大的和通用的制造协议的基础上，不同的微米和纳米级制造模块的选择性集成。 这些模块包括聚合物微压印和纳米压印（“自上而下”方法），以及纳米多孔二氧化硅的表面自组装和生物分子附着（“自下而上”方法），用于大规模生产聚合物或聚合物/二氧化硅纳米多孔微器件（NMD），其具有颗粒状结构，具有明确的非球形3D几何形状，纳米级扩散孔/通道和分子靶向功能。 与传统的球形微米和纳米颗粒相比，这些颗粒状NMD将提供更大的多面表面积以增加功能性，明确的颗粒形状以更好地控制流动动力学，以及高度特异性的靶向和释放能力。 关键问题的基础研究，如在微米和纳米尺度上处理生物降解和生物相容性聚合物的科学;聚合物微/纳米压印的建模;以及通过纳米孔/通道控制药物释放的纳米流体。该研究将由一个跨学科团队进行，该团队包括五名来自生物医学工程，化学工程，在微/纳米制造、纳米尺度加工和测量、界面现象和分子自组装、生物分子和表面活性剂以及多相流化方面具有专业知识的机械工程部门。 虽然这项研究将集中在药物输送装置的制造上，但同样的方法可以很容易地应用于各种BioMEMS（生物传感器，生物反应器，组织支架）或其他MEMS/NEMS装置。