DISSERTATION RESEARCH: Vertical and Horizontal Transmission and Parasite Virulence in a Plant/fungus Interaction

论文研究：植物/真菌相互作用中的垂直和水平传播以及寄生虫毒力

• 批准号: 0309240
• 负责人: Keith Clay
• 金额: $ 0.4万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0309240&HistoricalAwards=false
• 关键词: DISSERTATION; RESEARCH; Vertical; Horizontal; Transmission

Most theories on the evolution of parasite virulence assume a positive relationship between transmission success of the parasite and its virulence, but there are few experimental tests of this relationship. Understanding the degree to which the host, versus the parasite, controls transmission mode would contribute substantially to models of parasite evolution by testing this common assumption. This research exploits a variable plant-fungus interaction to explore the phenotypic and genetic relationships between virulence and transmission mode (horizontal or vertical). Experiments are planned to determine if horizontal transmission is positively related to parasite virulence, the relationship between horizontal transmission and vertical transmission, if parasite growth rate predicts transmission success or parasite virulence, and if the parasite or the host - or their interaction - controls the mode of parasite transmission. The proposed studies will provide empirical data on the relationship between parasite transmission mode and virulence, which is broadly applicable to human health and agriculture. The project will support the training and development of a non-traditional graduate student.

大多数关于寄生虫毒力进化的理论假设寄生虫的传播成功与其毒力之间存在正相关关系，但很少有实验测试这种关系。了解宿主与寄生虫控制传播模式的程度，将通过测试这一共同假设，对寄生虫进化模型做出重大贡献。本研究利用一种可变的植物-真菌相互作用来探索毒力和传播模式（水平或垂直）之间的表型和遗传关系。计划进行实验，以确定水平传播是否与寄生虫毒力呈正相关，水平传播和垂直传播之间的关系，如果寄生虫的生长速度预测传输成功或寄生虫毒力，如果寄生虫或主机-或它们的相互作用-控制寄生虫传播的模式。这些研究将为寄生虫传播方式与毒力之间的关系提供经验数据，广泛适用于人类健康和农业。该项目将支持非传统研究生的培训和发展。