Brassinosteroid-Auxin Synergism to Dissect Hormone Response Pathways in Arabidopsis

植物对光环境极为敏感。最近在P.I.的研究研究表明，植物激素生长素和油菜素类固醇（BRs）密切相关地调节了幼苗对光的反应。生长素和BR通路已经分别进行了一些详细的研究，但它们之间存在显著的空白。本项目旨在确定生长素和BR信号通路之间可能共享的成分。主要目的是：(1)利用现有的生理和遗传工具表征br -生长素在拟南芥中的相互作用；(2)揭示两种激素利用的新的信号转导成分。本研究将探讨这些激素之间的相互作用在调节基因表达、细胞扩增和分裂以及血管分化等多种反应中的影响。长期目标是完全了解调节幼苗发育的信号网络，并将其与其他生物信号转导的一般机制联系起来。

Plants are exquisitely sensitive to their light environment. Recent studies in the P.I.'s laboratory indicate that the plant hormones auxin and brassinosteroids (BRs) act in close proximity to modulate the seedling light response. The auxin and BR pathways have been studied individually in some detail, but significant gaps in each pathway exist. This project aims to identify components that may be shared between the auxin and BR signaling pathways. The primary aims are: (1) to characterize the BR-auxin interaction in Arabidopsis using existing physiological and genetic tools and (2) to uncover novel signal transduction components utilized by both hormones. This research will address the impact of the interaction between these hormones in regulating such diverse responses as changes in gene expression, cell expansion and division, and vascular differentiation. The long-term objective is to completely understand the signaling networks that regulate seedling development, and to relate this to general mechanisms of signal transduction in other organisms.