Brassinosteroid-Auxin Synergism to Dissect Hormone Response Pathways in Arabidopsis

植物对它们的光环境非常敏感。P.I.的最新研究的实验室表明，植物激素生长素和油菜素类固醇（BR）的作用非常接近，以调节幼苗的光反应。生长素和BR途径已分别进行了一些详细的研究，但在每个途径中存在显着的差距。 该项目旨在确定生长素和BR信号通路之间可能共享的组件。主要目标是：（1）利用现有的生理学和遗传学工具来表征拟南芥中BR-生长素的相互作用，以及（2）揭示这两种激素所利用的新的信号转导组分。这项研究将解决这些激素之间的相互作用在调节基因表达，细胞扩增和分裂，血管分化的变化等不同的反应的影响。 长期目标是完全了解调节幼苗发育的信号网络，并将其与其他生物体中信号转导的一般机制联系起来。

Plants are exquisitely sensitive to their light environment. Recent studies in the P.I.'s laboratory indicate that the plant hormones auxin and brassinosteroids (BRs) act in close proximity to modulate the seedling light response. The auxin and BR pathways have been studied individually in some detail, but significant gaps in each pathway exist. This project aims to identify components that may be shared between the auxin and BR signaling pathways. The primary aims are: (1) to characterize the BR-auxin interaction in Arabidopsis using existing physiological and genetic tools and (2) to uncover novel signal transduction components utilized by both hormones. This research will address the impact of the interaction between these hormones in regulating such diverse responses as changes in gene expression, cell expansion and division, and vascular differentiation. The long-term objective is to completely understand the signaling networks that regulate seedling development, and to relate this to general mechanisms of signal transduction in other organisms.