Purchase of a 400 MHz NMR Spectrometer

凯斯西储大学化学系将获得一台400兆赫核磁共振光谱仪，该奖项来自主要研究仪器（MRI）项目。该设备将使研究人员能够开展以下研究：a)醌依赖性含铜胺氧化酶：机制和抑制；B)杂烷基自由基不对称合成；C) α -螺旋肽核酸；D)有机合成中的有机铁配合物；E)将无机单元整合到共轭有机聚合物中，以修饰有机发光二极管的性能；f)复合寡糖和糖缀合物的合成，以及以碳水化合物为基础的癌症疫苗的开发。核磁共振（NMR）波谱是化学家用来研究分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。这些核磁共振研究的结果将对合成有机化学、药物化学和材料科学产生影响。

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Case Western Reserve University will acquire a 400 MHz NMR Spectrometer. This equipment will enable researchers to carry out research on a) quinone-dependent copper-containing amine oxidases: mechanism and inhibition; b) asymmetric synthesis with heteroalkyl radicals; c) alpha-helical peptide nucleic acids; d) organiron complexes in organic synthesis; e) the integration of inorganic units into conjugated organic polymers to modify properties of organic light emitting diodes; and f) the synthesis of complex oligosaccharides and glycoconjugates, and the development of carbohydrate-based cancer vaccines. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic chemistry, medicinal chemistry and materials science.