Purchase of a 400 MHz NMR Spectrometer

凯斯西储大学化学系将从主要研究仪器(MRI)计划获得这一奖项，以获得一台400 MHz的核磁共振光谱仪。这台设备将使研究人员能够开展以下方面的研究：a)依赖于醌的含铜胺氧化酶：机理和抑制；b)杂烷基不对称合成；c)α-螺旋多肽核酸；d)有机铁配合物在有机合成中的应用；e)将无机单元整合到共轭有机聚合物中以改变有机发光二极管的性能；以及f)复杂寡糖和糖共轭化合物的合成，以及碳水化合物癌症疫苗的开发。核磁共振波谱是化学家用来阐明分子结构的最有力的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机化学、药物化学和材料科学产生影响。

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Case Western Reserve University will acquire a 400 MHz NMR Spectrometer. This equipment will enable researchers to carry out research on a) quinone-dependent copper-containing amine oxidases: mechanism and inhibition; b) asymmetric synthesis with heteroalkyl radicals; c) alpha-helical peptide nucleic acids; d) organiron complexes in organic synthesis; e) the integration of inorganic units into conjugated organic polymers to modify properties of organic light emitting diodes; and f) the synthesis of complex oligosaccharides and glycoconjugates, and the development of carbohydrate-based cancer vaccines. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic chemistry, medicinal chemistry and materials science.