Purchase of a 400 MHz NMR Spectrometer

有了这个主要研究仪器（MRI）计划的奖项，凯斯西储大学化学系将获得一台400 MHz NMR光谱仪。该设备将使研究人员能够开展以下研究：a）依赖醌的含铜胺氧化酶：机理和抑制; B）杂烷基自由基的不对称合成; c）α-螺旋肽核酸; d）有机合成中的有机铁络合物; e）将无机单元整合到共轭有机聚合物中以改变有机发光二极管的特性;和f）合成复合寡糖和糖缀合物，以及开发基于碳水化合物的癌症疫苗。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对合成有机化学、药物化学和材料科学产生影响。

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Case Western Reserve University will acquire a 400 MHz NMR Spectrometer. This equipment will enable researchers to carry out research on a) quinone-dependent copper-containing amine oxidases: mechanism and inhibition; b) asymmetric synthesis with heteroalkyl radicals; c) alpha-helical peptide nucleic acids; d) organiron complexes in organic synthesis; e) the integration of inorganic units into conjugated organic polymers to modify properties of organic light emitting diodes; and f) the synthesis of complex oligosaccharides and glycoconjugates, and the development of carbohydrate-based cancer vaccines. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic chemistry, medicinal chemistry and materials science.