REQUEST TO PURCHASE A 400 MHZ NMR SPECTROMETER

描述（由申请人提供）：位于圣路易斯的华盛顿大学（WU）是美国顶尖的研究机构之一，它的两个主校区——丹佛斯和医疗中心——相距三英里，为广泛的研究提供支持。吴高分辨率核磁共振设备是吴唯一开放的溶液态分析和结构核磁共振应用资源。二十多年来，它每年都为来自两个校区的40多个独立的化学、生化和生物医学研究小组提供服务。然而，由于核磁共振设施的整套仪器仅位于丹佛斯校区，吴的医学中心校园的研究人员不能立即访问附近的核磁共振分析，这是现代生物导向的合成化学所需要的。事实证明，这对正在进行的NIH资助的研究来说是一个重大的困难和实质性的障碍。为了解决这个问题，吴核磁共振设施要求NCRR SIG资助购买一台400 MHz核磁共振光谱仪，位于吴医学中心校园。这是第一次，吴医学中心校园的研究人员可以方便、即时地使用这种强大的分析技术。该应用程序是在NIH资助的WU医学中心校园研究人员的敦促下编写的，他们需要显著增强对分析和结构NMR工具的访问。该提案要求资金244,680美元，加上内部配套资金80,000美元，足以购买所要求的仪器，400兆赫（9.4特斯拉）瓦里安公司（帕洛阿尔托）DirectDrive系统。在过去十年中，核磁共振仪器技术的进步，特别是在超导磁体和杜瓦设计、数字控制和通信领域，以适度的成本提供了非凡的光谱仪能力。“DirectDrive”架构代表了瓦里安新一代的控制台技术，它利用了过去十年中数字电子技术的巨大进步。将所要求的仪器定位在吴医学中心校园将立即并显着受益于正在进行的NIH资助的研究项目，将多功能和强大的溶液状态核磁共振分析工具带入吴的生物医学研究者社区的核心。

DESCRIPTION (provided by applicant): Washington University (WU) in St Louis is among the nation's top research institutions and supports extensive research at its two primary campuses, Danforth and medical center, which are separated from each other by a distance of three miles. The WU High Resolution Nuclear Magnetic Resonance Facility is the University's only open access resource for solution-state analytical and structural NMR applications. Each year for over two decades it has served in excess of 40 separate chemical, biochemical and biomedical research groups from both campuses. Nevertheless, because the NMR Facility's entire suite of instrumentation is located solely on the Danforth Campus, WU's medical center campus researchers have not had immediate nearby access to NMR analysis, as is required of modern, biologically oriented, synthetic chemistry. This has proven to be a significant hardship and substantive hindrance to ongoing NIH funded research. To address this problem, the WU NMR Facility requests NCRR SIG funding to purchase a 400 MHz NMR spectrometer to be located at the WU medical center campus. For the first time, WU medical center campus researchers will have convenient and immediate access to this powerful analytical technique. This application was written at the urging of established, NIH funded, WU medical center campus researchers who require significantly enhanced access to analytical and structural NMR tools. The proposal requests funds of $244,680, which combined with internal matching funds of $80,000 are sufficient to purchase the requested instrument, a 400 MHz (9.4 tesla) Varian, Inc. (Palo Alto) DirectDrive" system. Advances in NMR instrument technology during the past decade, in particular in the areas of superconducting magnet and dewar design, and digital control and communications, provide extraordinary spectrometer capabilities at modest cost. The DirectDrive" architecture represents a new generation of console technology from Varian, one that leverages the tremendous advances in digital electronics of the past decade. Locating the requested instrument at the WU medical center campus will immediately and significantly benefit ongoing NIH funded research programs, bringing the versatile and powerful tools of solution-state NMR analysis into the heart of WU's biomedical investigator community.