SGER: Tissue Engineering of Sponge Cells for Biopharmaceuticals

Blanch0337080海绵含有丰富的化合物，具有很高的潜在治疗价值。在过去的十年里，从海绵提取物中分离出了具有强大的抗有丝分裂、抗病毒和抗菌特性的化合物。然而，由于环境和可获得性的限制，没有足够的海绵生物量来提取这些化合物用于测试和临床试验。到目前为止，还没有永生化的海绵细胞系，细胞培养技术还处于初级阶段。本项目旨在应用现代组织工程技术，特别是三维支架材料的最新进展，对海绵Axinella corrugata进行细胞体外培养的探索性研究。

Blanch0337080Sea sponges are a prolific source of compounds with high potential therapeutic value. Over the past decade, compounds have been isolated from sponge extracts with potent anti-mitotic, anti viral and antibacterial properties. However, due to environmental constraints and accessibility, insufficient sponge biomass is available from which to extract these compounds for testing and clinical trials. To date, there are no immortalized sponge cell lines and techniques for cell cultivation are still in their infancy. This project is to carry out exploratory studies on the adaptation of modern tissue engineering techniques, particularly the recent developments in three-dimensional scaffold materials, to cultivate cells of the sea sponge Axinella corrugata in vitro.