SGER: Tissue Engineering of Sponge Cells for Biopharmaceuticals

海海绵是一种丰富的化合物来源，具有很高的潜在治疗价值。在过去的十年中，从海绵提取物中分离出的化合物具有有效的抗有丝分裂、抗病毒和抗菌特性。然而，由于环境限制和可及性，海绵生物量不足，无法从中提取这些化合物进行测试和临床试验。到目前为止，还没有长生不老的海绵细胞系，细胞培养技术仍处于起步阶段。本项目拟对现代组织工程技术，特别是三维支架材料的最新进展，在体外培养海绵瓦楞纸轴藻细胞方面进行探索性研究。

Blanch0337080Sea sponges are a prolific source of compounds with high potential therapeutic value. Over the past decade, compounds have been isolated from sponge extracts with potent anti-mitotic, anti viral and antibacterial properties. However, due to environmental constraints and accessibility, insufficient sponge biomass is available from which to extract these compounds for testing and clinical trials. To date, there are no immortalized sponge cell lines and techniques for cell cultivation are still in their infancy. This project is to carry out exploratory studies on the adaptation of modern tissue engineering techniques, particularly the recent developments in three-dimensional scaffold materials, to cultivate cells of the sea sponge Axinella corrugata in vitro.