Enzyme Design and Catalytic Function for the Production of Novel Materials

这个合作项目， 伯克利和加州大学旧金山分校的工作人员 旨在生产新的聚合物 具有有用性质的肽。 调查员都很优秀 科学家们，虽然都很好， 其他赠款支持。 在 克雷克博士还有另一个 美国国家科学基金会赠款， 在这项提案中的努力。 私家侦探已经发展出酶促的 氨基酸的反应方法 在有机溶剂中的酯， 游离氨基酸生成 二肽 该方法已 延伸到四肽，但是 该战略似乎不太可能 生产有用的聚合物，尽管 简单地说， 缩氨酸 应注意 不能使用羧肽酶 在这样的合成中， 无酰基酶 中间体 有一些有趣的想法， 这一建议，但实用性 合成多肽 这些方法似乎微不足道。

This collaborative project between workers at Berkeley and UCSF is designed to produce new polymeric peptides with useful properties. The investigators are all excellent scientists, although all well supported by other grants. In particular Dr. Craik has another NSF grant which duplicates his effort in this proposal. The P.I. has developed enzymatic methods for reacting amino acid esters in organic solvents with free amino acids to generate dipeptides. The approach has been extended to a tetra peptide, but the strategy seems unlikely to produce useful polymers, although it might be practical for short peptides. It should be noted that carboxypeptidase cannot be employed in such syntheses because it does not have and acyl enzyme intermediate. There are some interesting ideas in this proposal, but the practicality of synthesizing polypeptides by these approaches seems minimal.