Engineering Protein Aggregation and Fibril Formation
Engineering Protein Aggregation and Fibril Formation
批准号:
0432625
负责人:
Harvey Blanch
金额:
$49.92万
依托单位国家:
美国
项目类别:
Continuing Grant
财政年份:
2005
资助国家:
美国
项目状态:
已结题
起止时间:
2005-07-15 至 2008-06-30
中文摘要
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英文摘要
0432625BlanchThe goal of this proposed research is investigate the roles of primary sequence and conformational characteristics in determining protein aggregation behavior. The specific objectives are directed toward experimental and theoretical investigations of the underlying mechanisms. The ultimate goal is to control aggregation. To assist in uncovering forces and mechanisms essential to manipulate protein aggregation properties, the proposed research focuses on the effects of sequence patterns and solution parameters that impact the competition between aggregation and refolding. The experimental work will be performed on multiple systems of interest, including short oligopeptides as well as specific regions of three different proteins, all of which are suitable candidates for studies of aggregation.
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SGER: Tissue Engineering of Sponge Cells for Biopharmaceuticals
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批准号:0337080
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项目类别:Standard Grant
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资助金额:$5.05万
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财政年份:2003
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负责人:Harvey Blanch
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依托单位:
Thermodynamics and Kinetics of Protein Aggregation
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批准号:0118208
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项目类别:Continuing Grant
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资助金额:$56.76万
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财政年份:2001
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负责人:Harvey Blanch
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依托单位:
Thermodynamics and Kinetics of Protein Aggregations
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批准号:9901054
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项目类别:Continuing Grant
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资助金额:$39.87万
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财政年份:1999
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负责人:Harvey Blanch
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依托单位:
Molecular Thermodynamics of Protein Interactions; Applications to Protein Separations
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批准号:9530793
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项目类别:Continuing Grant
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资助金额:$73.99万
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财政年份:1996
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负责人:Harvey Blanch
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依托单位:
Bio-Molecular Thermodynamics of Protein Precipitation in Aqueous Solutions
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批准号:9214653
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项目类别:Continuing Grant
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资助金额:$18.0万
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财政年份:1993
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负责人:Harvey Blanch
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依托单位:
Enzyme Design and Catalytic Function for the Production of Novel Materials
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批准号:9119237
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项目类别:Continuing Grant
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资助金额:$68.4万
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财政年份:1992
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负责人:Harvey Blanch
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依托单位:
Molecular Thermodynamics of Protein Precipitation in AqueousSolution
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批准号:8914849
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项目类别:Continuing Grant
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资助金额:$30.5万
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财政年份:1990
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负责人:Harvey Blanch
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依托单位:
Support of the Tenth Enzyme Engineering Conference, September 24-29, l989
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批准号:8912237
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项目类别:Standard Grant
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资助金额:$1.5万
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财政年份:1989
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负责人:Harvey Blanch
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依托单位:
Enzyme Design and Catalytic Function for Production of NovelMaterials
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批准号:8807179
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项目类别:Continuing Grant
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资助金额:$76.62万
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财政年份:1988
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负责人:Harvey Blanch
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依托单位:
Engineering Research Equipment Grant: Low-Angle Laser Light-Scattering Photometer and HPLC Size Exclusion Chromatography System
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批准号:8705530
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项目类别:Standard Grant
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资助金额:$8.09万
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财政年份:1987
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负责人:Harvey Blanch
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依托单位:
Travel to Attend: Ninth Engineering Foundation Conference on Enzyme Engineering to be held in Santa Barbara, California, October 4-9, 1987
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批准号:8705074
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项目类别:Standard Grant
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资助金额:$1.6万
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财政年份:1987
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负责人:Harvey Blanch
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依托单位:
Mass Transfer and Thermodynamics for Biological Production of Chemicals
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批准号:8715908
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项目类别:Continuing Grant
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资助金额:$20.0万
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财政年份:1987
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负责人:Harvey Blanch
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依托单位:
Industry/University Cooperative Research Project: Thermo- dynamics and Transport for Reaction and Recovery of Biomolecules in Aqueous and Non-Aqueous Systems
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批准号:8513642
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项目类别:Standard Grant
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资助金额:$17.0万
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财政年份:1986
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负责人:Harvey Blanch
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依托单位:
Engineering Research Equipment Grant: High Performance Liquid Chromatography
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批准号:8505848
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项目类别:Standard Grant
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资助金额:$4.8万
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财政年份:1985
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负责人:Harvey Blanch
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依托单位:
Bubble Coalescence in Gas Liquid Contactors
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批准号:8313334
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项目类别:Continuing Grant
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资助金额:$18.58万
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财政年份:1984
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负责人:Harvey Blanch
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依托单位:
Special Foreign Currency Travel Support (In Indian Currency)To Attend the Symposium on Future Resources of Raw Materials; Bombay, India; March 22-31, 1980
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批准号:7926506
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项目类别:Standard Grant
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资助金额:$0.19万
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财政年份:1980
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负责人:Harvey Blanch
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依托单位:
Bubble Size and Fungal Morphology in Fermentation Systems
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批准号:7912024
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项目类别:Continuing Grant
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资助金额:$13.23万
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财政年份:1980
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负责人:Harvey Blanch
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依托单位:
Mechanism and Kinetics of Hydrocarbon Utilization By Microorganisms
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批准号:7910114
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项目类别:Standard Grant
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资助金额:$0.71万
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财政年份:1979
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负责人:Harvey Blanch
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依托单位:
Engineering Foundation Conference--Mass Transfer and Scale-Up of Fermentations
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批准号:7710037
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项目类别:Standard Grant
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资助金额:$1.0万
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财政年份:1977
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负责人:Harvey Blanch
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依托单位:
Non-Newtonian Fermentation Mixtures: Mass Transfer and Rheology
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批准号:7617004
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项目类别:Standard Grant
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资助金额:$11.63万
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财政年份:1976
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负责人:Harvey Blanch
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依托单位:
国内基金
海外基金
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