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Engineering Protein Aggregation and Fibril Formation

Engineering Protein Aggregation and Fibril Formation
工程蛋白质聚集和原纤维形成
批准号:
0432625
负责人:
Harvey Blanch
金额:
$49.92万
依托单位国家:
美国
项目类别:
Continuing Grant
财政年份:
2005
资助国家:
美国
项目状态:
已结题
起止时间:
2005-07-15 至 2008-06-30

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中文摘要
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英文摘要
0432625BlanchThe goal of this proposed research is investigate the roles of primary sequence and conformational characteristics in determining protein aggregation behavior. The specific objectives are directed toward experimental and theoretical investigations of the underlying mechanisms. The ultimate goal is to control aggregation. To assist in uncovering forces and mechanisms essential to manipulate protein aggregation properties, the proposed research focuses on the effects of sequence patterns and solution parameters that impact the competition between aggregation and refolding. The experimental work will be performed on multiple systems of interest, including short oligopeptides as well as specific regions of three different proteins, all of which are suitable candidates for studies of aggregation.
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SGER: Tissue Engineering of Sponge Cells for Biopharmaceuticals
  • 批准号:
    0337080
  • 项目类别:
    Standard Grant
  • 资助金额:
    $5.05万
  • 财政年份:
    2003
  • 负责人:
    Harvey Blanch
  • 依托单位:
Thermodynamics and Kinetics of Protein Aggregation
  • 批准号:
    0118208
  • 项目类别:
    Continuing Grant
  • 资助金额:
    $56.76万
  • 财政年份:
    2001
  • 负责人:
    Harvey Blanch
  • 依托单位:
Thermodynamics and Kinetics of Protein Aggregations
  • 批准号:
    9901054
  • 项目类别:
    Continuing Grant
  • 资助金额:
    $39.87万
  • 财政年份:
    1999
  • 负责人:
    Harvey Blanch
  • 依托单位:
Molecular Thermodynamics of Protein Interactions; Applications to Protein Separations
  • 批准号:
    9530793
  • 项目类别:
    Continuing Grant
  • 资助金额:
    $73.99万
  • 财政年份:
    1996
  • 负责人:
    Harvey Blanch
  • 依托单位:
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    32372636
  • 项目类别:
    面上项目
  • 资助金额:
    50.00万元
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    2023
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    郭慧娟
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  • 资助金额:
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  • 负责人:
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