Industry/University Cooperative Research Project: Thermo- dynamics and Transport for Reaction and Recovery of Biomolecules in Aqueous and Non-Aqueous Systems

该项目涉及两个重要领域， 开发生物工艺生产高， 中等价值的生物化学品 第一个问题涉及使用水性 用于回收发酵产物的两相聚合物系统。 研究的目的是获得分子热力学 这些解决方案的性质，并开发预测模型， 相行为和溶质分子在相之间的分配。 第二个领域涉及使用非水溶剂来增强聚合物的分散性。 酶催化反应中的底物溶解度。 超临界二氧化碳，单独与选定的吸收剂， 作为溶剂用于研究几种商业上 重要反应：胆固醇氧化， 脂质和各种水解反应，这些反应可以“反向”进行。

This project is concerned with two areas of importance in the development of bioprocesses for the production of high and intermediate-value biochemicals. The first concerns the use of aqueous two-phase polymer systems for the recovery of fermentation products. The research is directed at obtaining the molecular thermodynamic properties of these solutions and developing predictive models for phase behavior and partitioning of solute molecules between phases. The second area concerns the use of non-aqueous solvents for enhancing substrate solubility in enzymatically catalyzed reactions. Supercritical carbon dioxide, alone with selected entrainers, is used as a solvent for studying the kinetics of several commercially important reactions: cholesterol oxidation, interesterification of lipids, and various hydrolytic reactions which can be run "backwards".